Pregled bibliografske jedinice broj: 1111865
Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis
Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis // Alpe-Adria Rectors Conference (AARC) – International PhD Scientific Conference „Innovative technologies in biomedicine“
Rijeka, Hrvatska, 2019. str. /-/ (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1111865 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Chlorogenic acid ameliorates experimental
colitis in mice by suppressing
signaling pathways involved in inflammatory
response and apoptosis
Autori
Vukelić, Iva ; Detel, Dijana ; Batičić, Lara ; Potočnjak, Iva ; Buljević, Sunčica ; Domitrović, Robert
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
Alpe-Adria Rectors Conference (AARC) – International PhD Scientific Conference „Innovative technologies in biomedicine“
Mjesto i datum
Rijeka, Hrvatska, 19.09.2019. - 20.09.2019
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Chlorogenic acid ; Inflammatory bowel disease ; DSS-Induced colitis ; Apoptosis ; Oxidative stress
Sažetak
Chlorogenic acid (ChA) has multitude beneficial effects, however, underlying mechanisms by which ChA could influence the inflammation in colitis are still unknown. To investigate this, we induced colitis in mice by administration of dextran sulfate sodium (DSS) in drinking water. Oral administration of ChA significantly ameliorated clinical symptoms of DSS-induced colitis and colon shortening. ChA administration resulted in a suppression of phosphorylated extracellular signal-regulated kinases 1 and 2 (ERK1/2), c-Jun N-terminal kinases 1 and 2 (JNK1/2), Akt and signal transducer and activator of transcription 3 (STAT3) with concomitant upregulation of phosphatase and tensin homolog (PTEN) expression. ChA decreased the expression and nuclear translocation of nuclear factor-kappa B (NF-κB) p65 subunit and the expression of tumor necrosis factor-alpha (TNF-α). Induction of apoptosis and oxidative stress was attenuated by ChA through the suppression of of Bax, caspase-8, caspase-9 and heme oxygenase-1 (HO- 1) expression. The results of this study suggest that ChA could be used for the treatment of colitis by suppressing activation of pro-inflammatory and apoptotic signaling pathways.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Farmacija
POVEZANOST RADA
Projekti:
MEDRI--uniri-biomed-18-30 - Interakcija lijekova i fitokemikalija in vitro i in vivo: uloga FOXO signalnog puta (Domitrović, Robert, MEDRI ) ( CroRIS)
--uniri-biomed-18-114 - Uloga novootkrivenih proteaza u razvoju i progresiji tumora debelog crijeva (Detel, Dijana) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Lara Batičić
(autor)
Dijana Detel
(autor)
Iva Potočnjak
(autor)
Iva Vukelić
(autor)
Robert Domitrović
(autor)
Sunčica Buljević
(autor)