Naslov
Discriminatory potential of IgG N-glycosylation in chronic graft-versus-disease

Autori
Prenc, Ema ; Pulanic, Drazen ; Ugrina, Ivo ; Desnica, Lana ; Bakovic, Maja Pucic ; Stambuk, Jerko ; Milosevic, Milan ; Seiwerth, Ranka Serventi ; Durakovic, Nadira ; Peric, Zinaida ; Vrhovac, Radovan ; Nemet, Damir ; Lauc, Gordan ; Pavletic, Steven Z.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, prošireni sažetak, znanstveni

Izvornik
Bone marrow transplantation. Supplement, Volume: 53. / - , 2018, 406-408

Skup
The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation

Mjesto i datum
Lisabon, Portugal, 18.03.2018. - 21.03.2018

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
glycan ; glycosylation ; graft versus host disease ; hematopoietic stem cell transplantation

Sažetak
Background Glycans, complex oligosaccharides, are directly involved in almost every biological process, have a fundamental role in the immune system and are probably involved in nearly every human disease. However, glycosylation has been greatly ignored in the area of allogeneic hematopoietic stem cell transplantation (alloHSCT) and graft versus host disease (GVHD). Both acute and chronic GVHD are multisystemic debilitating immunological disturbances arising after alloHSCT. Scope of Review In this paper we review the glycosylation research already done in the field of alloHSCT and GVHD, and evaluate further potential of glycan analysis in GVHD by looking into resembling inflammatory and autoimmune conditions. Major Conclusions Glycan research could bring significant improvement in alloHSCT procedure with reduction in following complications, such as GVHD. Identifying glycan patterns that induce self-tolerance and the ones that cause the auto- and allo-immune response could lead to innovative and tissue specific immunomodulative therapy instead of the current immunosuppressive treatment, enabling preservation of the graft-versus-tumor effect. Moreover, improved glycan pattern analyses could offer a more complete assessment and greatly needed dynamic biomarkers for GVHD. General Significance This review is written with a goal to encourage glycan research in the field of alloHSCT and GVHD as a perspective tool leading to improved engraftment, discovery of much needed biomarkers for GVHD, enabling an appropriate therapy and improved monitoring of therapeutic response.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA