Naslov
Protective effect of pentagastrin on stress induced gastric lesions in mice.

Autori
Giljanovic, Sanja ; Sikiric Predrag ; Senecic Irena ; Jagic, Vjekoslav ; Dodig, M ; Djermanovic, Zoran ; Komericki, Ljiljana ; Banic, Marko ; Brkic, Tomislav ; Erceg, Damir ; Djacic, Sanja ; Seiwerth, Sven ; Grabarevic, Zeljko ; Rotkvic, Ivo ; Duvnjak Marko ; Anic, Tomislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 2nd International Symposium on Neurology of the Brain-Gut Axis. From Basic Science to Clinical Perspectives / - , 1990, 1017-1017

Skup
Second International Symposium on Neurobiology of the Brain-Gut Axis: From Basic Science to Clinical Perspectives.

Mjesto i datum
Pečuh, Mađarska, 13.07.1990. - 14.07.1990

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pentagastrin, stress induced gastric lesions, protective effect
(pentagastrin, stress induced gastric lesions. protective effect)

Sažetak
All results suggesting the protective effect of pentagastrin were previously obtained in stressed rats. Therefore, we investigated its effect on gastric lesions in mice. Lesions were induced as described before (Ras~nen, Acta Physiol. Scand. 58, 201, 1963). Pentagastris (0.02, 0.2, 1.O mg/kg b.w.) was applied i.p. immediately before 3h- stress procedure. Control mice received an equivolume of saline (4.0 ml/kg b.w.i.p.). After sacrifice the gastric lesions were assessed as before (SIR rivet al., EJP 158, 61, 1988). Results. In comparison to the control values, pentagastrin does protect when is given in the highest dose. It was, however, uneffective in smaller doses. Conclusion. These results suggest that pentagastrin has a dose-dependent and not species related protective effect in stress. This is also consistent with well known trophic effect of gastrin in gastrointestinal tract.

Izvorni jezik
Engleski

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