Pregled bibliografske jedinice broj: 1108824
Healthy siblings of children with Crohn's disease exhibit more rapid changes in microbiota composition as a response to exclusive enteral nutrition
Healthy siblings of children with Crohn's disease exhibit more rapid changes in microbiota composition as a response to exclusive enteral nutrition // JPEN, Journal of parenteral and enteral nutrition, 45 (2021), 6; 1352-1363 doi:10.1002/jpen.1981 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1108824 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Healthy siblings of children with Crohn's disease
exhibit more rapid changes in microbiota
composition as a response to exclusive enteral
nutrition
Autori
Sila, Sara ; Jelić, Marko ; Trivić, Ivana ; Tambić Andrašević, Arjana ; Kolaček, Sanja ; Hojsak, Iva
Izvornik
JPEN, Journal of parenteral and enteral nutrition (0148-6071) 45
(2021), 6;
1352-1363
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Crohn's disease ; exclusive enteral nutrition ; microbiota
Sažetak
Background: The aim of this study was to determine the impact of exclusive enteral nutrition (EEN) on the microbiota composition of the newly diagnosed Crohn's disease (CD) patients and to determine the effect of EEN received for 2 days in siblings of patients with CD. Methods: Newly diagnosed pediatric CD patients (n = 17) and unaffected healthy siblings (n = 10) participated in the study. In CD patients, stool samples were collected at 3 time points: prior to therapy introduction, the second day of EEN therapy, and the last day of EEN therapy. In healthy siblings, stool samples were collected before the introduction of EEN and the second day of EEN. Molecular approach targeting 16S ribosomal RNA was used for analyzing the gut microbiota of participants' stool samples. Results: There was no significant difference in microbial diversity between children with CD and healthy siblings before EEN (P = .127 for HhaI digestion ; P = .604 for MspI digestion) as opposed to the second day of EEN (P = .006 HhaI digestion ; P = .023 MspI digestion). In healthy controls, significant changes in microbiota composition were apparent by the second day of EEN, contrary to children with CD, in whom similar changes in microbiota composition were apparent on the last day of EEN. Conclusion: EEN leads to significant microbiota changes in both healthy children and children with CD. Changes in microbiota composition occur more rapidly in healthy children, whereas in children with CD, significant changes were detected at the end of EEN.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
IP-2014-09-3788 - Kronične upalne bolesti crijeva u djece: incidencija, tijek bolesti te uloga prehrane i crijevne mikroflore u etiopatogenezi (PED-IBD) (HRZZ - 2014-09) ( CroRIS)
Ustanove:
Stomatološki fakultet, Zagreb,
Klinika za dječje bolesti Medicinskog fakulteta,
Medicinski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Medicinski fakultet, Osijek,
Klinika za dječje bolesti
Profili:
Sara Sila
(autor)
Ivana Trivić
(autor)
Marko Jelić
(autor)
Iva Hojsak
(autor)
Sanja Kolaček
(autor)
Arjana Tambić-Andrašević
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE