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Pregled bibliografske jedinice broj: 1108824

Healthy siblings of children with Crohn's disease exhibit more rapid changes in microbiota composition as a response to exclusive enteral nutrition


Sila, Sara; Jelić, Marko; Trivić, Ivana; Tambić Andrašević, Arjana; Kolaček, Sanja; Hojsak, Iva
Healthy siblings of children with Crohn's disease exhibit more rapid changes in microbiota composition as a response to exclusive enteral nutrition // JPEN, Journal of parenteral and enteral nutrition, 45 (2021), 6; 1352-1363 doi:10.1002/jpen.1981 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1108824 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Healthy siblings of children with Crohn's disease exhibit more rapid changes in microbiota composition as a response to exclusive enteral nutrition

Autori
Sila, Sara ; Jelić, Marko ; Trivić, Ivana ; Tambić Andrašević, Arjana ; Kolaček, Sanja ; Hojsak, Iva

Izvornik
JPEN, Journal of parenteral and enteral nutrition (0148-6071) 45 (2021), 6; 1352-1363

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Crohn's disease ; exclusive enteral nutrition ; microbiota

Sažetak
Background: The aim of this study was to determine the impact of exclusive enteral nutrition (EEN) on the microbiota composition of the newly diagnosed Crohn's disease (CD) patients and to determine the effect of EEN received for 2 days in siblings of patients with CD. Methods: Newly diagnosed pediatric CD patients (n = 17) and unaffected healthy siblings (n = 10) participated in the study. In CD patients, stool samples were collected at 3 time points: prior to therapy introduction, the second day of EEN therapy, and the last day of EEN therapy. In healthy siblings, stool samples were collected before the introduction of EEN and the second day of EEN. Molecular approach targeting 16S ribosomal RNA was used for analyzing the gut microbiota of participants' stool samples. Results: There was no significant difference in microbial diversity between children with CD and healthy siblings before EEN (P = .127 for HhaI digestion ; P = .604 for MspI digestion) as opposed to the second day of EEN (P = .006 HhaI digestion ; P = .023 MspI digestion). In healthy controls, significant changes in microbiota composition were apparent by the second day of EEN, contrary to children with CD, in whom similar changes in microbiota composition were apparent on the last day of EEN. Conclusion: EEN leads to significant microbiota changes in both healthy children and children with CD. Changes in microbiota composition occur more rapidly in healthy children, whereas in children with CD, significant changes were detected at the end of EEN.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
IP-2014-09-3788 - Kronične upalne bolesti crijeva u djece: incidencija, tijek bolesti te uloga prehrane i crijevne mikroflore u etiopatogenezi (PED-IBD) (HRZZ - 2014-09) ( CroRIS)

Ustanove:
Stomatološki fakultet, Zagreb,
Klinika za dječje bolesti Medicinskog fakulteta,
Medicinski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Medicinski fakultet, Osijek,
Klinika za dječje bolesti

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Sila, Sara; Jelić, Marko; Trivić, Ivana; Tambić Andrašević, Arjana; Kolaček, Sanja; Hojsak, Iva
Healthy siblings of children with Crohn's disease exhibit more rapid changes in microbiota composition as a response to exclusive enteral nutrition // JPEN, Journal of parenteral and enteral nutrition, 45 (2021), 6; 1352-1363 doi:10.1002/jpen.1981 (međunarodna recenzija, članak, znanstveni)
Sila, S., Jelić, M., Trivić, I., Tambić Andrašević, A., Kolaček, S. & Hojsak, I. (2021) Healthy siblings of children with Crohn's disease exhibit more rapid changes in microbiota composition as a response to exclusive enteral nutrition. JPEN, Journal of parenteral and enteral nutrition, 45 (6), 1352-1363 doi:10.1002/jpen.1981.
@article{article, author = {Sila, Sara and Jeli\'{c}, Marko and Trivi\'{c}, Ivana and Tambi\'{c} Andra\v{s}evi\'{c}, Arjana and Kola\v{c}ek, Sanja and Hojsak, Iva}, year = {2021}, pages = {1352-1363}, DOI = {10.1002/jpen.1981}, keywords = {Crohn's disease, exclusive enteral nutrition, microbiota}, journal = {JPEN, Journal of parenteral and enteral nutrition}, doi = {10.1002/jpen.1981}, volume = {45}, number = {6}, issn = {0148-6071}, title = {Healthy siblings of children with Crohn's disease exhibit more rapid changes in microbiota composition as a response to exclusive enteral nutrition}, keyword = {Crohn's disease, exclusive enteral nutrition, microbiota} }
@article{article, author = {Sila, Sara and Jeli\'{c}, Marko and Trivi\'{c}, Ivana and Tambi\'{c} Andra\v{s}evi\'{c}, Arjana and Kola\v{c}ek, Sanja and Hojsak, Iva}, year = {2021}, pages = {1352-1363}, DOI = {10.1002/jpen.1981}, keywords = {Crohn's disease, exclusive enteral nutrition, microbiota}, journal = {JPEN, Journal of parenteral and enteral nutrition}, doi = {10.1002/jpen.1981}, volume = {45}, number = {6}, issn = {0148-6071}, title = {Healthy siblings of children with Crohn's disease exhibit more rapid changes in microbiota composition as a response to exclusive enteral nutrition}, keyword = {Crohn's disease, exclusive enteral nutrition, microbiota} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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