Naslov
Lipofilnost lijekova. I dio : Važnost lipofilnosti u istraživanju novih lijekova
(Lipophilicity of drugs. Part I)

Autori
Medić-Šarić, Marica ; Franić, Danijela ; Debeljak, Željko

Izvornik
Farmaceutski glasnik (0014-8202) 54 (1998), 2; 37-51

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
lipofilnost; koeficijent razdiobe; log P; Hanschova metoda; Rekkerova metoda; shake flask metoda
(lipophilicity; partition coefficient; log P; Hansch's method; Rekker's method; shake flask method)

Izvorni jezik
Hrvatski

Znanstvena područja
Farmacija

Napomena
Lipophilicity is a prime physicochemical descriptor of xenobiotics with relevance to their biological properties. The hydrophobic interaction of drugs with a receptor and the toxicological properties are examples of a steadily increasing number of topics in which lipophilicity plays an important role. A number of theoretical and empirical approaches have been developed during the last twenty years for calculation of Log P values. The most common experimental method for determining the equilibria of drugs partitioning between water and n-octanol is shake flask method. In this context calculative approaches are superior to experimental procedures.

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