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Pregled bibliografske jedinice broj: 1106979

Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages


Manček-Keber, Mateja; Ribić, Rosana; Chain, Fernando; Sinnaeve, Davy; Martins, José C.; Jerala, Roman; Tomić, Srđanka; Fehér, Krisztina
Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages // Molecules, 25 (2020), 16; 3707, 10 doi:10.3390/molecules25163707 (međunarodna recenzija, članak, znanstveni)


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Naslov
Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages

Autori
Manček-Keber, Mateja ; Ribić, Rosana ; Chain, Fernando ; Sinnaeve, Davy ; Martins, José C. ; Jerala, Roman ; Tomić, Srđanka ; Fehér, Krisztina

Izvornik
Molecules (1420-3049) 25 (2020), 16; 3707, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
peptidoglycan ; immunostimulation ; lipid incapsulation ; adamantane ; mannose

Sažetak
We report the enhancement of the lipopolysaccharide-induced immune response by adamantane containing peptidoglycan fragments in vitro. The immune stimulation was detected by Il-6 (interleukine 6) and RANTES (regulated on activation, normal T cell expressed and secreted) chemokine expression using cell assays on immortalized mouse bone-marrow derived macrophages. The most active compound was a alpha- D-mannosyl derivative of an adamantylated tripeptide with L-chirality at the adamantyl group attachment, whereby the mannose moiety assumed to target mannose receptors expressed on macrophage cell surfaces. The immune co-stimulatory effect was also influenced by the configuration of the adamantyl center, revealing the importance of specific molecular recognition event taking place with its receptor. The immunostimulating activities of these compounds were further enhanced upon their incorporation into lipid bilayers, which is likely related to the presence of the adamantyl group that helps anchor the peptidoglycan fragment into lipid nanoparticles. We concluded that the proposed adamantane containing peptidoglycan fragments act as co- stimulatory agents and are also suitable for the preparation of lipid nanoparticle-based delivery of peptidoglycan fragments.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-7899 - Sinteza, strukturna analiza i biološka evaluacija peptidomimetika i glikonjugata (PEPTGLYCOSAR) (Tomić-Pisarović, Srđanka, HRZZ - 2014-09) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Manček-Keber, Mateja; Ribić, Rosana; Chain, Fernando; Sinnaeve, Davy; Martins, José C.; Jerala, Roman; Tomić, Srđanka; Fehér, Krisztina
Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages // Molecules, 25 (2020), 16; 3707, 10 doi:10.3390/molecules25163707 (međunarodna recenzija, članak, znanstveni)
Manček-Keber, M., Ribić, R., Chain, F., Sinnaeve, D., Martins, J., Jerala, R., Tomić, S. & Fehér, K. (2020) Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages. Molecules, 25 (16), 3707, 10 doi:10.3390/molecules25163707.
@article{article, author = {Man\v{c}ek-Keber, Mateja and Ribi\'{c}, Rosana and Chain, Fernando and Sinnaeve, Davy and Martins, Jos\'{e} C. and Jerala, Roman and Tomi\'{c}, Sr\djanka and Feh\'{e}r, Krisztina}, year = {2020}, pages = {10}, DOI = {10.3390/molecules25163707}, chapter = {3707}, keywords = {peptidoglycan, immunostimulation, lipid incapsulation, adamantane, mannose}, journal = {Molecules}, doi = {10.3390/molecules25163707}, volume = {25}, number = {16}, issn = {1420-3049}, title = {Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages}, keyword = {peptidoglycan, immunostimulation, lipid incapsulation, adamantane, mannose}, chapternumber = {3707} }
@article{article, author = {Man\v{c}ek-Keber, Mateja and Ribi\'{c}, Rosana and Chain, Fernando and Sinnaeve, Davy and Martins, Jos\'{e} C. and Jerala, Roman and Tomi\'{c}, Sr\djanka and Feh\'{e}r, Krisztina}, year = {2020}, pages = {10}, DOI = {10.3390/molecules25163707}, chapter = {3707}, keywords = {peptidoglycan, immunostimulation, lipid incapsulation, adamantane, mannose}, journal = {Molecules}, doi = {10.3390/molecules25163707}, volume = {25}, number = {16}, issn = {1420-3049}, title = {Adamantane Containing Peptidoglycan Fragments Enhance RANTES and IL-6 Production in Lipopolysaccharide-Induced Macrophages}, keyword = {peptidoglycan, immunostimulation, lipid incapsulation, adamantane, mannose}, chapternumber = {3707} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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