Pregled bibliografske jedinice broj: 1106183
Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin
Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin // Adriatic NMR Conference : Book of Abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena (ur.).
Zagreb: Kemijski odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu ; Geološki odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu, 2020. str. 41-41 (poster, domaća recenzija, sažetak, znanstveni)
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Naslov
Synthesis, structure characterization and interactions of 4“-aminopropyl derivative of azithromycin
Autori
Gašperov, Jana ; Mikulandra, Ivana ; Jednačak, Tomislav ; Bertoša, Branimir ; Habinovec, Iva ; Novak, Predrag
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Adriatic NMR Conference : Book of Abstracts
/ Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb : Kemijski odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu ; Geološki odsjek Prirodoslovno-matematičkog fakulteta Sveučilišta u Zagrebu, 2020, 41-41
ISBN
978-953-6076-58-1
Skup
4th Adriatic NMR conference 2020
Mjesto i datum
Peroj, Hrvatska; Vodnjan, Hrvatska, 22.09.2020. - 24.09.2020
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
macrozones ; synthesis ; structure ; characterization
Sažetak
Azithromycin belongs to macrolide class of antibiotics wich exert its biological activity by binding to bacterial ribosome at or near the peptidyl transferase center thus inhibiting protein biosynthesis. They are effective in treating infections caused by Gram-positive and some Gram-negative bacteria. Due to the increased development of bacterial resistance much effort is directed towards the discovery of new more potent antibiotics. A series of bioactive azithromycin derivatives, the new class of macrozones have been prepared by coupling thiosemicarbazones to azithromycin at position 4" (Figure 1). Here we present their synthesis, characterization and interactions of macrozone precursor, 4"-aminopropyl azithromycin with the ribosome isolated from E. Coli. A combination of NMR experiments such as saturation transfer difference (STD) and transferred nuclear Overhauser effect spectroscopy (trNOESY) and molecular modeling were applied to determine binding epitopes and explore bound conformations.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2018-01-8098 - Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije (Makrozoni/Macrozones) (Novak, Predrag, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb
Profili:
Iva Habinovec (autor)
Branimir Bertoša (autor)
Tomislav Jednačak (autor)
Ivana Mikulandra (autor)
Predrag Novak (autor)