Naslov
Type 2 diabetes and viral infection; cause and effect of disease

Autori
Turk Wensveen, Tamara ; Gašparini, Dora ; Rahelić, Dario ; Wensveen, Felix M.

Izvornik
Diabetes research and clinical practice (0168-8227) 172 (2021); 108637, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
antidiabetic drugs ; COVID-19 ; corona virus ; diabetes ; diabetes mellitus type 2 ; immune defects ; immune system ; immunometabolism ; infection ; insulin resistance ; T2D ; viral infection

Sažetak
The recent pandemic of COVID-19 has made abundantly clear that Type 2 diabetes (T2D) increases the risk of more frequent and more severe viral infections. At the same time, pro- inflammatory cytokines of an anti-viral Type-I profile promote insulin resistance and form a risk factor for development of T2D. What this illustrates is that there is a reciprocal, detrimental interaction between the immune and endocrine system in the context of T2D. Why these two systems would interact at all long remained unclear. Recent findings indicate that transient changes in systemic metabolism are induced by the immune system as a strategy against viral infection. In people with T2D, this system fails, thereby negatively impacting the antiviral immune response. In addition, immune-mediated changes in systemic metabolism upon infection may aggravate glycemic control in T2D. In this review, we will discuss recent literature that sheds more light on how T2D impairs immune responses to viral infection and how virus-induced activation of the immune system increases risk of development of T2D.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA