Naslov
An in vitro and in silico evaluation of bioactive potential of cornelian cherry (Cornus mas L.) extracts rich in polyphenols and iridoids

Autori
Blagojević, Bojana ; Agić, Dejan ; Serra, Ana Teresa ; Matić, Sara ; Matovina, Mihaela ; Bijelić, Sandra ; Popović, Boris M.

Izvornik
Food chemistry (0308-8146) 335 (2021); 127619, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cornelian cherry ; Cornus mas ; Antioxidants ; HT29 ; α-Amylase ; α-Glucosidase ; Dipeptidyl peptidase III

Sažetak
In the present research, seven different cornelian cherry (Cornus mas L.) cultivars and selections were examined. In vitro and in silico methods were applied for determining and correlating phytochemical constituents and biological potential. Loganic acid, cornuside, cyanidin 3-galactoside, and pelargonidin 3- galactoside were determined as the most dominant compounds, presenting ≥90% of the all detected iridoid and phenolic constituents in the extracts. Cornelian cherry fruits were characterized by high antioxidant capacity and antiproliferative activity on human colon cancer cells (HT29). It was observed the strong inhibitory potential of α-amylase, α- glucosidase, and dipeptidyl peptidase III (DPP III) enzyme activities. Principal component analysis (PCA) was used as a very helpful tool to discriminate the constituents with the highest contribution to tested bioactivities and to highlight the most potent genotypes. PCA, together with binding energies measurements and docking analysis, pointed out pelargonidin 3-robinobioside as the strongest inhibitor of α-glucosidase.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Biotehnologija, Prehrambena tehnologija

POVEZANOST RADA