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Pregled bibliografske jedinice broj: 1104923

Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells

Ouwendijk, Werner J. D.; Dekker, Lennard J. M.; van den Ham, Henk-Jan; Lenac Rovis, Tihana; Haefner, Erik S.; Jonjic, Stipan; Haas, Jürgen; Luider, Theo M.; Verjans, Georges M. G. M.
Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells // Frontiers in Microbiology, 11 (2020), PMID: 32547533, 10 doi:10.3389/fmicb.2020.01179 (međunarodna recenzija, članak, znanstveni)

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Naslov
Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells

Autori
Ouwendijk, Werner J. D. ; Dekker, Lennard J. M. ; van den Ham, Henk-Jan ; Lenac Rovis, Tihana ; Haefner, Erik S. ; Jonjic, Stipan ; Haas, Jürgen ; Luider, Theo M. ; Verjans, Georges M. G. M.

Izvornik
Frontiers in Microbiology (1664-302X) 11 (2020); PMID: 32547533, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
epidermal growth factor ; herpes simplex virus 1 ; mass-spectrometry ; retinal pigment epithelial cells ; varicella-zoster virus

Sažetak
Herpes simplex virus 1 (HSV-1) and varicella- zoster virus (VZV) are two closely related human alphaherpesviruses that persistently infect most adults worldwide and cause a variety of clinically important diseases. Herpesviruses are extremely well adapted to their hosts and interact broadly with cellular proteins to regulate virus replication and spread. However, it is incompletely understood how HSV-1 and VZV interact with the host proteome during productive infection. This study determined the temporal changes in virus and host protein expression during productive HSV-1 and VZV infection in the same cell type. Results demonstrated the temporally coordinated expression of HSV-1 and VZV proteins in infected cells. Analysis of the host proteomes showed that both viruses affected extracellular matrix composition, transcription, RNA processing and cell division. Moreover, the prominent role of epidermal growth factor receptor (EGFR) signaling during productive HSV-1 and VZV infection was identified. Stimulation and inhibition of EGFR leads to increased and decreased virus replication, respectively. Collectively, the comparative temporal analysis of viral and host proteomes in productively HSV-1 and VZV-infected cells provides a valuable resource for future studies aimed to identify target(s) for antiviral therapy development.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Stipan Jonjić (autor)

Avatar Url Tihana Lenac Roviš (autor)

Poveznice na cjeloviti tekst rada:

doi www.frontiersin.org

Citiraj ovu publikaciju:

Ouwendijk, Werner J. D.; Dekker, Lennard J. M.; van den Ham, Henk-Jan; Lenac Rovis, Tihana; Haefner, Erik S.; Jonjic, Stipan; Haas, Jürgen; Luider, Theo M.; Verjans, Georges M. G. M.
Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells // Frontiers in Microbiology, 11 (2020), PMID: 32547533, 10 doi:10.3389/fmicb.2020.01179 (međunarodna recenzija, članak, znanstveni)
Ouwendijk, W., Dekker, L., van den Ham, H., Lenac Rovis, T., Haefner, E., Jonjic, S., Haas, J., Luider, T. & Verjans, G. (2020) Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells. Frontiers in Microbiology, 11, PMID: 32547533, 10 doi:10.3389/fmicb.2020.01179.
@article{article, author = {Ouwendijk, Werner J. D. and Dekker, Lennard J. M. and van den Ham, Henk-Jan and Lenac Rovis, Tihana and Haefner, Erik S. and Jonjic, Stipan and Haas, J\"{u}rgen and Luider, Theo M. and Verjans, Georges M. G. M.}, year = {2020}, pages = {10}, DOI = {10.3389/fmicb.2020.01179}, chapter = {PMID: 32547533}, keywords = {epidermal growth factor, herpes simplex virus 1, mass-spectrometry, retinal pigment epithelial cells, varicella-zoster virus}, journal = {Frontiers in Microbiology}, doi = {10.3389/fmicb.2020.01179}, volume = {11}, issn = {1664-302X}, title = {Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells}, keyword = {epidermal growth factor, herpes simplex virus 1, mass-spectrometry, retinal pigment epithelial cells, varicella-zoster virus}, chapternumber = {PMID: 32547533} }
@article{article, author = {Ouwendijk, Werner J. D. and Dekker, Lennard J. M. and van den Ham, Henk-Jan and Lenac Rovis, Tihana and Haefner, Erik S. and Jonjic, Stipan and Haas, J\"{u}rgen and Luider, Theo M. and Verjans, Georges M. G. M.}, year = {2020}, pages = {10}, DOI = {10.3389/fmicb.2020.01179}, chapter = {PMID: 32547533}, keywords = {epidermal growth factor, herpes simplex virus 1, mass-spectrometry, retinal pigment epithelial cells, varicella-zoster virus}, journal = {Frontiers in Microbiology}, doi = {10.3389/fmicb.2020.01179}, volume = {11}, issn = {1664-302X}, title = {Analysis of Virus and Host Proteomes During Productive HSV-1 and VZV Infection in Human Epithelial Cells}, keyword = {epidermal growth factor, herpes simplex virus 1, mass-spectrometry, retinal pigment epithelial cells, varicella-zoster virus}, chapternumber = {PMID: 32547533} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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