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Pregled bibliografske jedinice broj: 1103583

An alternative synthesis of the non-small cell lung carcinoma drug afatinib

Kovacevic, Tatjana; Mesic, Milan; Avdagic, Amir; Zegarac, Miroslav
An alternative synthesis of the non-small cell lung carcinoma drug afatinib // Tetrahedron letters, 59 (2018), 47; 4180-4182 doi:10.1016/j.tetlet.2018.10.026 (međunarodna recenzija, članak, znanstveni)

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Naslov
An alternative synthesis of the non-small cell lung carcinoma drug afatinib

Autori
Kovacevic, Tatjana ; Mesic, Milan ; Avdagic, Amir ; Zegarac, Miroslav

Izvornik
Tetrahedron letters (0040-4039) 59 (2018), 47; 4180-4182

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
afatinib ; alternative synthesis ; cancer

Sažetak
Afatinib (BIBW2992, I) is the anticancer drug developed by Boehringer Ingelheim. This work is reporting the synthesis of the afatinib using a new route by Ullmann-Goldberg reaction from corresponding 4-anilinoquinazoline iodide as the last step in the synthesis. This route was not described previously and it could be used for synthesis of afatinib analogs.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti, Farmacija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA

Ustanove:
Pliva-Istraživački institut,
Fidelta d.o.o.

Profili:

Avatar Url Amir Avdagić (autor)

Avatar Url Tatjana Kovačević (autor)

Avatar Url Milan Mesić (autor)

Avatar Url Miroslav Žegarac (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Kovacevic, Tatjana; Mesic, Milan; Avdagic, Amir; Zegarac, Miroslav
An alternative synthesis of the non-small cell lung carcinoma drug afatinib // Tetrahedron letters, 59 (2018), 47; 4180-4182 doi:10.1016/j.tetlet.2018.10.026 (međunarodna recenzija, članak, znanstveni)
Kovacevic, T., Mesic, M., Avdagic, A. & Zegarac, M. (2018) An alternative synthesis of the non-small cell lung carcinoma drug afatinib. Tetrahedron letters, 59 (47), 4180-4182 doi:10.1016/j.tetlet.2018.10.026.
@article{article, author = {Kovacevic, Tatjana and Mesic, Milan and Avdagic, Amir and Zegarac, Miroslav}, year = {2018}, pages = {4180-4182}, DOI = {10.1016/j.tetlet.2018.10.026}, keywords = {afatinib, alternative synthesis, cancer}, journal = {Tetrahedron letters}, doi = {10.1016/j.tetlet.2018.10.026}, volume = {59}, number = {47}, issn = {0040-4039}, title = {An alternative synthesis of the non-small cell lung carcinoma drug afatinib}, keyword = {afatinib, alternative synthesis, cancer} }
@article{article, author = {Kovacevic, Tatjana and Mesic, Milan and Avdagic, Amir and Zegarac, Miroslav}, year = {2018}, pages = {4180-4182}, DOI = {10.1016/j.tetlet.2018.10.026}, keywords = {afatinib, alternative synthesis, cancer}, journal = {Tetrahedron letters}, doi = {10.1016/j.tetlet.2018.10.026}, volume = {59}, number = {47}, issn = {0040-4039}, title = {An alternative synthesis of the non-small cell lung carcinoma drug afatinib}, keyword = {afatinib, alternative synthesis, cancer} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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