Naslov
Mitochondrial unfolded protein response, mitophagy and other mitochondrial quality control mechanisms in heart disease and aged heart

Autori
Svaguša, Tomo ; Martinić, Mislav ; Martinić, Matea ; Kovačević, Lucija ; Šepac, Ana ; Miličić, Davor ; Bulum, Joško ; Starčević, Boris ; Sirotković-Skerlev, Maja ; Seiwerth, Fran ; Kulić, Ana ; Sedlić, Filip

Izvornik
Croatian Medical Journal (0353-9504) 61 (2020), 2; 126-138

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
mitochondria, mitochondrial quality control, mitophagy, myocardial infarction, heart failure

Sažetak
Mitochondria are involved in crucial homeostatic processes in the cell: the production of adenosine triphosphate and reactive oxygen species, and the release of pro-apoptotic molecules. Thus, cell survival depends on the maintenance of proper mitochondrial function by mitochondrial quality control. The most important mitochondrial quality control mechanisms are mitochondrial unfolded protein response, mitophagy, biogenesis, and fusion-fission dynamics. This review deals with mitochondrial quality control in heart diseases, especially myocardial infarction and heart failure. Some previous studies have demonstrated that the activation of mitochondrial quality control mechanisms may be beneficial for the heart, while others have shown that it may lead to heart damage. Our aim was to describe the mechanisms by which mitochondrial quality control contributes to heart protection or damage and to provide evidence that may resolve the seemingly contradictory results from the previous studies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA