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Pregled bibliografske jedinice broj: 1100737

Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells

Topić, Iva; Ikić, Marina; Ivčević, Sanja; Kovačić, Nataša; Marušić, Ana; Kušec, Rajko; Grčević, Danka
Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells // Leukemia Research, 37 (2013), 6; 705-712 doi:10.1016/j.leukres.2013.03.002 (međunarodna recenzija, članak, ostalo)

CROSBI ID: 1100737 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells

Autori
Topić, Iva ; Ikić, Marina ; Ivčević, Sanja ; Kovačić, Nataša ; Marušić, Ana ; Kušec, Rajko ; Grčević, Danka

Izvornik
Leukemia Research (0145-2126) 37 (2013), 6; 705-712

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
BMP, promyelocytic leukemia

Sažetak
We investigated the role of bone morphogenetic proteins (BMPs) in suppression of all-trans retinoic acid (ATRA)-mediated differentiation of leukemic promyelocytes. In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPε gene expression induced by ATRA. BMP and ATRA synergized in the induction of ID genes, causing suppression of differentiation. In primary acute promyelocytic leukemia bone-marrow samples, positive correlation of PML/RARα and negative of RARα with the expression of BMP-4, BMP-6 and ID genes were found. We concluded that BMPs may have oncogenic properties and mediate ATRA resistance by a mechanism that involves ID genes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
MZOS-108-1080229-0142 - Molekularni mehanizmi učinaka imunosnih poremećaja na kost (Grčević, Danka, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Rajko Kušec (autor)

Avatar Url Nataša Kovačić (autor)

Avatar Url Sanja Ivčević (autor)

Avatar Url Danka Grčević (autor)

Avatar Url Ana Marušić (autor)

Avatar Url Iva Topić (autor)

Avatar Url Marina Ikić Matijašević (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Topić, Iva; Ikić, Marina; Ivčević, Sanja; Kovačić, Nataša; Marušić, Ana; Kušec, Rajko; Grčević, Danka
Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells // Leukemia Research, 37 (2013), 6; 705-712 doi:10.1016/j.leukres.2013.03.002 (međunarodna recenzija, članak, ostalo)
Topić, I., Ikić, M., Ivčević, S., Kovačić, N., Marušić, A., Kušec, R. & Grčević, D. (2013) Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells. Leukemia Research, 37 (6), 705-712 doi:10.1016/j.leukres.2013.03.002.
@article{article, author = {Topi\'{c}, Iva and Iki\'{c}, Marina and Iv\v{c}evi\'{c}, Sanja and Kova\v{c}i\'{c}, Nata\v{s}a and Maru\v{s}i\'{c}, Ana and Ku\v{s}ec, Rajko and Gr\v{c}evi\'{c}, Danka}, year = {2013}, pages = {705-712}, DOI = {10.1016/j.leukres.2013.03.002}, keywords = {BMP, promyelocytic leukemia}, journal = {Leukemia Research}, doi = {10.1016/j.leukres.2013.03.002}, volume = {37}, number = {6}, issn = {0145-2126}, title = {Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells}, keyword = {BMP, promyelocytic leukemia} }
@article{article, author = {Topi\'{c}, Iva and Iki\'{c}, Marina and Iv\v{c}evi\'{c}, Sanja and Kova\v{c}i\'{c}, Nata\v{s}a and Maru\v{s}i\'{c}, Ana and Ku\v{s}ec, Rajko and Gr\v{c}evi\'{c}, Danka}, year = {2013}, pages = {705-712}, DOI = {10.1016/j.leukres.2013.03.002}, keywords = {BMP, promyelocytic leukemia}, journal = {Leukemia Research}, doi = {10.1016/j.leukres.2013.03.002}, volume = {37}, number = {6}, issn = {0145-2126}, title = {Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells}, keyword = {BMP, promyelocytic leukemia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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