Pregled bibliografske jedinice broj: 1097960
Redoks-svojstva ferocenom supstituiranih nukleobaza
Redoks-svojstva ferocenom supstituiranih nukleobaza // Kemija u industriji : časopis kemičara i tehnologa Hrvatske, 69 (2020), 13; P21-P29 doi:10.15255/KUI.2020.025 (međunarodna recenzija, članak, znanstveni)
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Naslov
Redoks-svojstva ferocenom supstituiranih nukleobaza
(Redox properties of ferrocene-substituted
nucleobases)
Autori
Toma, Mateja ; Vrček, Valerije
Izvornik
Kemija u industriji : časopis kemičara i tehnologa Hrvatske (0022-9830) 69
(2020), 13;
P21-P29
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
ferocenski konjugati nukleobaza ; redoks-potencijal ; reaktivne kisikove vrste ; ROS
(ferrocene-substituted purine-nucleobase ; redox potential ; reactive oxygen species ; ROS)
Sažetak
A series of ferrocene-substituted purine- nucleobase derivatives 1-10 were synthesized and their redox potential was measured by cyclic voltammetry. Measured compounds showed a reversible one-electron oxidation in the range of 330–470 mV. A difference of 100 mV between N7 and N9 regioisomers was observed. In order to examine the tendency of ferrocene-nucleobase conjugates to produce reactive oxygen species (ROS), an acellular screening with DCFH2-DA assay was carried out. The nucleobases coupled with ferrocene generated ROS, while neither ferrocene itself nor the nucleobases were active. Changing the substituents on the purine ring can significantly influence the ROS generation of ferrocene-substituted nucleobases, which support design of biologically active ferrocene-nucleobase conjugates.
Izvorni jezik
Hrvatski
Znanstvena područja
Kemija, Kemijsko inženjerstvo, Farmacija
Napomena
XIII. susret mladih kemijskih inženjera, Zagreb, 20-
-21. veljače 2020.
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-1137 - Kvantno-kemijski dizajn, priprava i biološka svojstva organometalnih derivata nukleobaza (OrDeN) (Vrček, Valerije, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Emerging Sources Citation Index (ESCI)
