Naslov
CASE REPORT: PRE-TRANSPLANT TESTING AND POST- TRANSPLANT MONITORING FOR AN HLA-IMMUNIZED RECIPIENT IN HEART TRANSPLANTATION

Autori
Jukić, Lucija ; Palfi, Biserka ; Skorić, Boško ; Burek Kamenarić, Marija

Izvornik
Molecular and experimental biology in medicine (2584-671X) 3 (2020), 1; 52-56

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, znanstveni

Ključne riječi
immunogenetics ; HLA antibodies ; sensitization ; DSA monitoring ; heart transplantation

Sažetak
We report the workflow of immunogenetic pre- transplant testing and post-transplant monitoring in the case of a recipient immunized to human leucocyte antigens (HLA) who was waitlisted for heart transplantation. The recipient underwent heart transplantation across preformed HLA class I Donor Specific Antibodies (DSAs) detected by solid phase Luminex screening method but not by complement dependent cytotoxicity (CDC) screening method. The CDC lymphocyte crossmatch, which was performed retrospectively, was a weak positive. Post-transplant DSA monitoring by Luminex method revealed the decrease of HLA-A1, A25 and B57 DSAs with, at the same time, an increase of HLA-B8 DSA, as well as weak transient non-DSA HLA-DP antibodies. This case presents the importance of extensive immunogenetic testing and monitoring for identifying recipients with increased immunological risk for successful heart transplantation.

Izvorni jezik
Engleski

POVEZANOST RADA