Pregled bibliografske jedinice broj: 1094712
Repetitive Traumatic Brain Injury Is Associated With TDP-43 Alterations, Neurodegeneration, and Glial Activation in Mice
Repetitive Traumatic Brain Injury Is Associated With TDP-43 Alterations, Neurodegeneration, and Glial Activation in Mice // Journal of neuropathology and experimental neurology, 80 (2021), 1; 2-14 doi:10.1093/jnen/nlaa130 (međunarodna recenzija, članak, znanstveni)
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Naslov
Repetitive Traumatic Brain Injury Is Associated
With TDP-43 Alterations, Neurodegeneration, and
Glial Activation in Mice
Autori
Rajič Bumber, Jelena ; Pilipović, Kristina ; Janković, Tamara ; Dolenec, Petra ; Gržeta, Nika ; Križ, Jasna ; Župan, Gordana
Izvornik
Journal of neuropathology and experimental neurology (0022-3069) 80
(2021), 1;
2-14
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Brain concussion ; Mouse ; Nerve degeneration ; Neuroglia ; TDP-43 protein
Sažetak
Increasing evidence points to a relationship between repetitive mild traumatic brain injury (mTBI), the Tar DNA binding protein 43 (TDP-43) pathology and some neurodegenerative diseases, but the underlying pathophysiological mechanisms are still unknown. We examined TDP- 43 regulation, neurodegeneration, and glial responses following repetitive mTBI in nontransgenic mice and in animals with overexpression of human mutant TDP-43 protein (TDP-43G348C). In the frontal cortices of the injured nontransgenic animals, early TDP-43 cytoplasmatic translocation and overexpression of the protein and its pathological forms were detected. In the injured animals of both genotypes, neurodegeneration and pronounced glial activity were detected in the optic tract. In TDP-43G348C mice, these changes were significantly higher at day 7 after the last mTBI compared with the values in the nontransgenic animals. Results of this study suggest that the changes in the TDP-43 regulation in the frontal cortices of the nontransgenic animals were a transient stress response to the brain injury. Repetitive mTBI did not produce additional TDP-43 dysregulation or neurodegeneration or pronounced gliosis in the frontal cortex of TDP-43G348C mice. Our research also suggests that overexpression of mutated human TDP-43 possibly predisposes the brain to more intense neurodegeneration and glial activation in the optic tract after repetitive mTBI.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-4602 - Blaga repetitivna traumatska ozljeda mozga: model za istraživanje neuropatologije i neuroupale posredovane s TDP-43 (TDP-43repTBI) (Župan, Gordana, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Petra Dolenec
(autor)
Jelena Rajič Bumber
(autor)
Gordana Župan
(autor)
Tamara Janković
(autor)
Jasna Križ
(autor)
Nika Gržeta
(autor)
Kristina Pilipović
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE