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Pregled bibliografske jedinice broj: 1094564

Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high- dose methotrexate-possible role of low activity ABC and SLC drug transporters


Bielen, Luka; Kralj, Ivan; Ćurčić, Ela; Vodanović, Marijo; Boban, Ana; Božina, Nada
Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high- dose methotrexate-possible role of low activity ABC and SLC drug transporters // European journal of clinical pharmacology, 74 (2018), 9; 1191-1192 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1094564 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high- dose methotrexate-possible role of low activity ABC and SLC drug transporters

Autori
Bielen, Luka ; Kralj, Ivan ; Ćurčić, Ela ; Vodanović, Marijo ; Boban, Ana ; Božina, Nada

Izvornik
European journal of clinical pharmacology (0031-6970) 74 (2018), 9; 1191-1192

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
methotrexate ; drug transporters ; drug side effects ; genetic polymorphism ; drug- drug interactions

Sažetak
Here, we present a 26-year-old male with B cell ALL who after the second infusion of HD-MTX (5000 mg/m2 IV) and extremely high MTX serum concentration (142.56 μmol/L) suffered damage to four organ systems. We elaborated that it could have been due to combination of genetic predisposition and pharmacokinetic interactions between MTX and concomitant drugs (pantoprazole, ketoprofen, ciprofloxacin, and later with piperacillin/tazobactam. Slow MTX elimination ensued during the next 16 days. Subsequently, the patient developed AKI (with a fall of estimated glomerular filtration rate to 45 mL/min/1.73 m2), severe neutropenia, and a rise in alanine aminotransferase (234 U/L) followed by encephalopathy syndrome. The patient was found to be homozygous for SLCO1B1 T521C, ABCB1 G2677T/A, C3435T, C1236T, ABCC2 G1249A, low activity transporters alleles and heterozygous for MTHFR C677T and A1298C. A strong genetic predisposition to prolonged MTX elimination in combination with clinically significant pharmacokinetic interactions could explains extremely elevated MTX concentration, prolonged elimination and adverse MTX side effects.

Izvorni jezik
Engleski



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Ela Ćurčić (autor)

Avatar Url MARIJO VODANOVIĆ (autor)

Avatar Url Luka Bielen (autor)

Avatar Url Nada Božina (autor)

Avatar Url Ana Boban (autor)

Avatar Url Ivan Kralj (autor)


Citiraj ovu publikaciju:

Bielen, Luka; Kralj, Ivan; Ćurčić, Ela; Vodanović, Marijo; Boban, Ana; Božina, Nada
Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high- dose methotrexate-possible role of low activity ABC and SLC drug transporters // European journal of clinical pharmacology, 74 (2018), 9; 1191-1192 (međunarodna recenzija, članak, znanstveni)
Bielen, L., Kralj, I., Ćurčić, E., Vodanović, M., Boban, A. & Božina, N. (2018) Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high- dose methotrexate-possible role of low activity ABC and SLC drug transporters. European journal of clinical pharmacology, 74 (9), 1191-1192.
@article{article, author = {Bielen, Luka and Kralj, Ivan and \'{C}ur\v{c}i\'{c}, Ela and Vodanovi\'{c}, Marijo and Boban, Ana and Bo\v{z}ina, Nada}, year = {2018}, pages = {1191-1192}, keywords = {methotrexate, drug transporters, drug side effects, genetic polymorphism, drug- drug interactions}, journal = {European journal of clinical pharmacology}, volume = {74}, number = {9}, issn = {0031-6970}, title = {Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high- dose methotrexate-possible role of low activity ABC and SLC drug transporters}, keyword = {methotrexate, drug transporters, drug side effects, genetic polymorphism, drug- drug interactions} }
@article{article, author = {Bielen, Luka and Kralj, Ivan and \'{C}ur\v{c}i\'{c}, Ela and Vodanovi\'{c}, Marijo and Boban, Ana and Bo\v{z}ina, Nada}, year = {2018}, pages = {1191-1192}, keywords = {methotrexate, drug transporters, drug side effects, genetic polymorphism, drug- drug interactions}, journal = {European journal of clinical pharmacology}, volume = {74}, number = {9}, issn = {0031-6970}, title = {Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high- dose methotrexate-possible role of low activity ABC and SLC drug transporters}, keyword = {methotrexate, drug transporters, drug side effects, genetic polymorphism, drug- drug interactions} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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