Pregled bibliografske jedinice broj: 1094564
Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high- dose methotrexate-possible role of low activity ABC and SLC drug transporters
Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high- dose methotrexate-possible role of low activity ABC and SLC drug transporters // European journal of clinical pharmacology, 74 (2018), 9; 1191-1192 (međunarodna recenzija, članak, znanstveni)
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Naslov
Acute kidney injury, agranulocytosis,
drug-induced liver injury, and posterior
reversible encephalopathy syndrome caused by
high-
dose methotrexate-possible role of low activity
ABC and SLC drug transporters
Autori
Bielen, Luka ; Kralj, Ivan ; Ćurčić, Ela ; Vodanović, Marijo ; Boban, Ana ; Božina, Nada
Izvornik
European journal of clinical pharmacology (0031-6970) 74
(2018), 9;
1191-1192
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
methotrexate ; drug transporters ; drug side effects ; genetic polymorphism ; drug- drug interactions
Sažetak
Here, we present a 26-year-old male with B cell ALL who after the second infusion of HD-MTX (5000 mg/m2 IV) and extremely high MTX serum concentration (142.56 μmol/L) suffered damage to four organ systems. We elaborated that it could have been due to combination of genetic predisposition and pharmacokinetic interactions between MTX and concomitant drugs (pantoprazole, ketoprofen, ciprofloxacin, and later with piperacillin/tazobactam. Slow MTX elimination ensued during the next 16 days. Subsequently, the patient developed AKI (with a fall of estimated glomerular filtration rate to 45 mL/min/1.73 m2), severe neutropenia, and a rise in alanine aminotransferase (234 U/L) followed by encephalopathy syndrome. The patient was found to be homozygous for SLCO1B1 T521C, ABCB1 G2677T/A, C3435T, C1236T, ABCC2 G1249A, low activity transporters alleles and heterozygous for MTHFR C677T and A1298C. A strong genetic predisposition to prolonged MTX elimination in combination with clinically significant pharmacokinetic interactions could explains extremely elevated MTX concentration, prolonged elimination and adverse MTX side effects.
Izvorni jezik
Engleski
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
Ela Ćurčić
(autor)
MARIJO VODANOVIĆ
(autor)
Luka Bielen
(autor)
Nada Božina
(autor)
Ana Boban
(autor)
Ivan Kralj
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE