Pregled bibliografske jedinice broj: 1093083
Efficacy of a seawater enriched with copper, hyaluronic acid and eucalyptus against nasal pathogens
Efficacy of a seawater enriched with copper, hyaluronic acid and eucalyptus against nasal pathogens // Rhinology Online, 2 (2019), 119-124 doi:10.4193 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1093083 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Efficacy of a seawater enriched with copper, hyaluronic acid and eucalyptus against nasal pathogens
Autori
Huang, Song ; Constant Samuel ; DeServi, Barbara ; Meloni, Marisa ; Čulig, Josip ; Saaid, Amina
Izvornik
Rhinology Online (2589-5613) 2
(2019);
119-124
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
hypertonic seawater ; nasal irrigation ; Staphylococcus aureus ; common cold ; rhinovirus ; HRV-A16
Sažetak
Background: Common cold is the most common disease which mainly affects the upper respiratory system. It is caused by viral or, in a small percentage, by bacterial infections. Current therapy options focus on symptomatic relief of the disease such as nasal saline irrigation, an easy-to-apply, comfortable, non-toxic method. In this study, a novel hypertonic seawater solution enriched with hyaluronic acids, eucalyptus oil, copper and manganese salts, Stérimar Stop & Protect Cold and Flu (SSPCF), has been investigated with respect to efficacy against viral and microbial infections. Methodology: An in vitro 3D reconstituted human nasal epithelium tissue model, MucilAir™, has been used in this study. Pre-treatment and post-treatment anti-viral effects of SSPCF was measured through HRV-A16 viral load assays in order to evaluate the preventive and therapeutic efficacy of SSPCF, respectively. Anti-bacterial effects of SSPCF was assessed via S. aureus growth inhibition and fluorescence bead-based phagocytosis assays. Results: One-hour SSPCF treatment pre- or post-viral infection inhibited the viral replication up to 99.78 and 59.91%, respectively. S. aureus growth was completely eliminated (100%) in SSPCF treated tissues after 1 hour of treatment. Phagocytosis rate was 3.28 folds higher in SSPCF treated tissue as compared to saline treated controls. Conclusions: Under the conditions of this in vitro study, SSPCF appears effective against some species of rhinoviruses (as in common cold) and S. aureus in
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
