Naslov
The prevalence and risk factors for peripheral artery disease in chronic kidney disease in HIV-infected persons

Autori
Višković, Klaudija ; Marinelli, Annibale ; Nedeljko, Katrin ; Javorić, Ivana ; Bogdanić, Nikolina ; Zekan, Šime ; Begovac, Josip

Izvornik
Journal of the International AIDS Society (1758-2652) 23 (2020), Suppl. 7; 70-71

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ostalo, ostalo

Ključne riječi
HIV ; peripheral artery disease ; chronic kidney disease

Sažetak
Background: Cardiovascular disease is an important cause of morbidity among an ageing HIV population [1]. Despite the current evidence and known risk factors it is still challenging to determine to what extent HIV infection increases risk of peripheral artery disease (PAD)in comparison to general population. Here we examined the associa- tion between HIV infection, PAD and chronic kidney disease (CKD) in predominantly male HIV-infected persons compared with uninfected population. We also analysed risk factors related to PAD. Materials and methods: The cohort was comprised of 191 persons≥18 years old: 50 HIV-infected patients from the University Hospital for Infectious Diseases (UHID) in Zagreb and 141 non-HIV-infected patients from the Nephrology and Dialysis Department, Riuniti Hospital, Italy. HIV care in Croatia is centralised and all people living with HIV are treated at the UHID. Included were HIV- infected patients from 1 February 2018 to 30 September 2019, and non-HIV-infected patients from 4 September 2007 to 18 March 2019. CKD was defined as an eGFR of less than 60 mL/min/1.73 m2on at least two occasions 90 days apart. PAD was assessed using duplex color Doppler and was defined as having any of focal or diffuse medial or intimal calcification in iliac, common femoral, superficial femoral or tibial artery, diagnosed by grey scale vascular ultrasound. PAD was also considered present if there were haemodynamically significant stenosis or occlusion. Results: Of 191 participants 57.6% (110/191) were male with median age of 51 (IQR: 42 to 57) years. Fifty were HIV-infected (25 hadCKD) and of 141 non-HIV-infected 68 had CKD. The prevalence ofPAD was 76% (19/25, HIV+ CKD- yes), 32% (8/25, HIV+ CKD-no), 22% (15/68, HIV- CKD-yes) and 14% (10/73, HIV- CKD-no). BothHIV infection and CKD were associated with PAD (Table 1). Multivari-able analysis showed a significant interaction of body mass index(BMI) and CKD indicating that patients with CKD had more frequently PAD than those without CKD up to a BMI of 30 kg/m2. Conclusions: HIV-infected persons have PAD more frequently than non-HIV-infected patients and CKD worsens the findings. HIV infection and CKD are independent risk factors for PAD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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