Naslov
The role of clinical signs and self reported symptoms in prediction of metal allergic sensitization in orthodontic patients

Autori
Žigante, Martina ; Saltović, Ema ; Muhvić Urek, Miranda ; Špalj, Stjepan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta stomatol Croat. 2021 ; 55(1):91-102. / - , 2020, 100-100

Skup
7. međunarodni kongres Hrvatskog stomatološkog društva Hrvatskog liječničkog zbora i 4. kongres Hrvatskog društva za oralnu medicinu i patologiju HLZ-a

Mjesto i datum
Zagreb, Hrvatska, 13.11.2020. - 15.11.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
titanium ; nickel ; allergic sensitization ; clinical signs

Sažetak
AIM: This research aimed to assess the predictors of titanium and nickel allergic sensitization in patients in orthodontic treatment. MATERIALS AND METHODS: A total of 250 patients undergoing orthodontic treatment were invited to participate and 235 accepted (67% female). Patch test was performed on the allergens: nickel sulfate, titanium, titanium dioxide, titanium oxalate, titanium nitride, and petrolatum as control. Clinical signs such as exfoliative cheilitis, gingival hyperplasia, exfoliative glossitis, and self-reported symptoms (self- reported change or weakened sense of smell, change or weakened sense of taste, metallic taste, oral sensations such as pain or oral burning, dry mouth, gastrointestinal symptoms of swollen abdomen or pain in the abdomen and diarrhea, typical symptoms of inhalation allergies such as sneezing, eye tearing and runny nose and neurological symptoms of headache, tinnitus or vertigo) potentially associated with allergies were assessed. RESULTS: Prevalence of allergic sensitization to titanium and/or nickel in orthodontic patients was 15, 5% (95% CI 11.5- 20.6%), less often to titanium than nickel (4.5% ; 95% CI 2.5-7.9% vs 13.5% ; 95% CI 9.8-18.3%). Predictors of metal allergic sensitization in patients undergoing orthodontic treatment were changed or weakened sense of smell (OR= 6.3, 95%CI 1.2-34.7%, p=0.034), exfoliative cheilitis (OR=4.1, 95%CI 1.5-11.0%, p=0.005), female sex (OR= 3.2, 95%CI 1.2-8.5%, p=0.023), eye tearing (OR=3.1, 95%CI 1.1-8.4%, p=0.030) and age (OR=2.3, 95%CI 1.0- 5.0%, p=0.041). When predictors were analyzed separately for these two metals, nickel sensitization predictors were adult age (OR=2.8 ; 95% CI 1.2-6.4% ; p=0.017) and exfoliative cheilitis (OR=3.3 ; 95%CI 1.2-9.1 ; p=0.021), while titanium sensitization predictors were changed or weakened sense of smell (OR=31.7 ; 95% CI 4.6- 220.1% ; p<0.001) and eye tearing (OR=7.4 ; 95% CI 1.5-37.7% ; p=0.015). CONCLUSION: Solely positive patch test cannot draw to a definite conclusion of allergy. However, self-reported symptoms of changed or weakened sense of smell, eye tearing, and exfoliative cheilitis could refer to metal allergy in orthodontic patients. ACKNOWLEDGEMENTS: This research was supported by Croatian Science Foundation under the grants IMUNODENT HRZZ-IP-2014-09-7500 and DOK-2018-01- 2531.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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