Naslov
Analysis of the cytokine levels in the cerebrospinal fluid of mild cognitive impairment and Alzheimer's disease patients

Autori
Španić, Ena ; Babić Leko, Mirjana ; Langer Horvat, Lea ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Neurologia Croatica 2020 ; 69 (Suppl. 2): 50. / Šimić, Goran ; Mimica, Ninoslav - Zagreb : Denona, 2020, 50-50

Skup
Croatian congress on Alzheimer's disease (CROCAD-20v)

Mjesto i datum
Online, 15.10.2020. - 16.10.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Alzheimer's disease ; bead- and flow-based dual-laser multiplex detection instrument ; cerebrospinal fluid ; chemokines ; cytokines ; neuroflammation

Sažetak
Alzheimer’s disease (AD) is characterized by elevated inflammation. The dysregulation of the inflammatory response is probably a better term because of the often-seen imbalance of immune mediators. The purpose of this preliminary study was to detect and see how certain CSF cytokine levels differ between AD, mild cognitive impairment (MCI) patients, and healthy controls (HC), and whether some groups of mediators are elevated in different stages of the disease. Using the Bio-Plex Pro Human Cytokine 48-Plex Screening Panel, we determined the levels of 25 cytokines in samples from 26 AD, 25 MCI patients, and 25 HC subjects. Out of 25 cytokines analyzed, nine of them (IL-8, IP-10, SCGF-b, SDF-1a, MCP-1, M-CSF, IL-3, IL-6, MIF) didn’t show a significant difference between groups, whereas all others were significantly elevated in AD patients (CTACK, GROa, IL-1α, HGF, IFN-γ, IL-1β, IL-7, IL-17A, SCF, IL-2Ra, IL-4, IL-13, IL-16, IL18, RANTES, TNF-α). Most of them belong to a group of pro-inflammatory factors, except HGF, IL-4, and IL-13. We hope that comparison of these findings with other reports will contribute to better understanding of the inflammation profile in AD and its prodromal stages.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti), Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA