Naslov
Diagnostic of hemorrhagic fever with renal syndrome in Croatia during 2002 outbreak

Autori
Cvetko, Lidija ; Globočnik, Tina ; Cebalo, Karin ; Matijević, Ivana ; Cebalo, Ljiljana ; Kosor, Ela ; Gotovac, Katja ; Baletić, Jagoda ; Jelačić, Jasenka ; Zgorelec, Renata ; Gagro, Alenka ; Sabioncello, Ante ; Rabatić, Sabina ; Avšič Županc, Tatjana ; Markotić, Alemka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - , 2002, 53-53

Skup
Annual Meeting of the Croatian Immunological Society 2002.

Mjesto i datum
Trakošćan, Hrvatska, 22.11.2002. - 24.11.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Sažetak
Hemorrhagic fever with renal syndrome (HFRS) is a systemic infectious disease caused by viruses of the genus Hantavirus, family Bunyaviridae. Puumala (PUUV) and Dobrava (DOBV) viruses are found to be causative agents of HFRS in Croatia. Since great HFRS outbreak in 1995, we have recorded only sporadic HFRS cases in Croatia until 2002 year when new HFRS epidemic appeared. For the diagnostic of suspected HFRS cases we used usual standard serological tests as IgM and IgG enzyme linked immunosorbent assay (ELISA) and indirect immunofluorescent assay (IFA). RT-PCR was used for confirmation in some cases and future phylogenetical analysis. At the same time a new diagnostic test (Point-of-care Puumala and Point-of-care Dobrava, ERILAB, Finland) - immunochromatographic test (ICH) has been introduced and evaluated. After 105 serum sampels were analysed agreement between the results of ICH test and other serological tests was about 75%. Further evaluation and standardisation of the test is neccessary to clarify the sensitivity and specificity of the test as well as congruence of the results between individual readers. Analysis of epidemiological and serological data showed that this was the largest HFRS outbreak in Croatia until now. It started with sporadic cases in January and February. The number of cases rose sharply during March and April, and was continuously maintained until September. Diagnosis was confirmed in 218 (46%) of 473 suspected HFRS patients most of whom were males 170 (78%) compared with 48 (22%) females. 95% of patients were infected with PUUV, while less than 5% were infected with DOBV. The HFRS cases occurred throughout the country, exept the costal area and islands. Most of them came from well known focal areas as Požega, Rijeka, Zagreb and Slavonski Brod. A new HFRS endemic area was recognized in Okučani-Ivanovac region.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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