Naslov
The role of monocytes/macrophages in immunopathogenesis of hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome

Autori
Markotić, Alemka ; Hensley, Lisa ; Anderson, Kevin ; Jelačić, Jasenka ; Gotovac, Katja ; Lukas, Davorka ; Puljiz, Ivan ; Gagro, Alenka ; Kuzman, Ilija ; Schmaljohn, Connie

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
3rd Croatian Congress on Infectious Diseases with international participation-abstract book / - Zagreb, 2002

Skup
3rd Croatian Congress on Infectious Diseases with international participation

Mjesto i datum
Dubrovnik, Hrvatska, 12.10.2002. - 15.10.2002

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
monocytes/macrophages; HFRS

Sažetak
Hantaviruses cause two severe human illnesses, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). Several studies support the view that HFRS/HPS are immunological mediated diseases. Monocytes/macrophages have the important role in the hantaviral spread from the primary site of infection. Until now, there is lack of evidence about the immune mechanisms in human monocytes activation. Our recent in vitro findings revealed that upon the infection of monocytes/macrophages with HFRS- and HPS-causing viruses they produced beta chemokines (CCL3, CCL4, CCL5). Simultaneous gene expression of their receptors (CCR1 and CCR5) suggested that produced chemokines might have not only paracrine, but also autocrine effect. Further research of the signaling pathways, may help us in better understanding of HFRS/HPS immunopathogenesis. We also found that HTV are capable of initiating dendritic cell (DC)-like differentiation of human peripheral blood monocytes upon the infection with HFRS- and HPS-causing viruses. DC are key players in induction and regulation of T cell responses. The presence of DC within the skin, the blood and partially within the mucosal surfaces identifies them as one of the cell populations with most likely to have the earliest contact with viruses during infection. Thus, DC may not be only involved in triggering primary antiviral immune reactions, but also in the propagation of viral infection and contribute to the pathogenesis of viral disease. In our ongoing research we try to reach the role of possible circulating blood DC in HFRS patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Veterinarska medicina

POVEZANOST RADA