Naslov
Intense physical exercise induces an anti-inflammatory change in IgG N-glycosylation profile

Autori
Tijardović, Marko ; Marijančević, Domagoj ; Bok, Danijel ; Kifer, Domagoj ; Lauc, Gordan ; Gornik, Olga ; Keser, Toma

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Glycoconjugate Journal / Sonnino, Sandro - New York (NY) : Springer, 2019, 371-371

Skup
25th International Symposium on Glycoconjugates (Glyco25)

Mjesto i datum
Milano, Italija, 25.08.2019. - 31.08.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
N-glycosylation ; IgG ; inflammation ; exercise

Sažetak
Exercise is known to improve many aspects of human health, including modulation of the immune system and inflammatory status. Despite the general understanding that exercise reduces inflammation, the relation of the two is not yet fully understood. N-glycosylation of immunoglobulin G (IgG) and total plasma proteins was previously shown to reflect changes in inflammatory pathways, which could provide valuable information to further clarify effects of exercise. In order to better understand the relationship between physical activity and inflammation, we examined the effect of intense exercise, in the form of repeated sprint training (RST), on IgG and total plasma proteins N-glycosylation. Twenty-nine male physical education students were separated into treatment (RST, N = 15) and control (N = 14) groups. The RST group completed a 6-week exercise protocol while the control group was instructed to refrain from organized physical activity for the duration of the study. Three blood samples were taken at different time points: prior to start of the training program, the final week of the exercise intervention, and at the end of the four-week recovery period. Following the recovery period IgG N-glycosylation profiles showed anti-inflammatory changes in RST group compared to the control group, which manifested as a decrease in agalactosylated and an increase in digalactosylated and monosialylated N-glycans. Observed changes show the potential of intense physical exercise to reduce levels of systemic basal inflammation, as well as the potential for IgG N-glycosylation to serve as a sensitive longitudinal systemic inflammation marker.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

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