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Pregled bibliografske jedinice broj: 1088299

Cellular antioxidant activity of olive pomace extracts: impact of gastrointestinal digestion and cyclodextrin encapsulation


Radić, Kristina; Vinković Vrček, Ivana; Pavičić, Ivan; Vitali Čepo, Dubravka
Cellular antioxidant activity of olive pomace extracts: impact of gastrointestinal digestion and cyclodextrin encapsulation // Molecules, 25 (2020), 12; 5027, 15 doi:10.3390/molecules25215027 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1088299 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cellular antioxidant activity of olive pomace extracts: impact of gastrointestinal digestion and cyclodextrin encapsulation

Autori
Radić, Kristina ; Vinković Vrček, Ivana ; Pavičić, Ivan ; Vitali Čepo, Dubravka

Izvornik
Molecules (1420-3049) 25 (2020), 12; 5027, 15

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
olive pomace extract ; cyclodextrin ; in vitro gastrointestinal digestion ; antioxidant

Sažetak
Olive pomace is a valuable secondary raw material rich in polyphenols, left behind after the production of olive oil. The present study investigated the protective effect of a polyphenolic extract from olive pomace (OPE) on cell viability and antioxidant defense of cultured human HepG2 cells submitted to oxidative stress induced by tert-butylhydroperoxide (tBOOH). The investigation considered possible matrix effects, impact of gastrointestinal digestion and cyclodextrin (CD) encapsulation. Pre-treatment of cells with OPE prevented cell damage and increased intracellular glutathione but did not affect the activity of glutathione peroxidase and superoxide dismutase. OPE matrix significantly enhanced cell protective e ects of major antioxidants, such as hydroxytyrosol (HTS), while cyclodextrin encapsulation enhanced activity of OPE against intracellular reactive oxygen species (ROS) accumulation. The obtained results show that OPE is more potent antioxidant in comparison to equivalent dose of main polyphenols (HTS and TS) and that increasing solubility of OPE polyphenols by CD encapsulation or digestion enhances their potential to act as intracellular antioxidants. Antioxidative protection of cells by OPE was primarily achieved through direct radical- scavenging/reducing actions rather than activation of endogenous defense systems in the cell.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija, Interdisciplinarne biotehničke znanosti



POVEZANOST RADA


Projekti:
HRZZ-UIP-2014-09-9143 - Održivi razvoj inovacije u hrani - valorizacija otpada masline (NutriOliWa) (Vitali Čepo, Dubravka, HRZZ - 2014-09) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Radić, Kristina; Vinković Vrček, Ivana; Pavičić, Ivan; Vitali Čepo, Dubravka
Cellular antioxidant activity of olive pomace extracts: impact of gastrointestinal digestion and cyclodextrin encapsulation // Molecules, 25 (2020), 12; 5027, 15 doi:10.3390/molecules25215027 (međunarodna recenzija, članak, znanstveni)
Radić, K., Vinković Vrček, I., Pavičić, I. & Vitali Čepo, D. (2020) Cellular antioxidant activity of olive pomace extracts: impact of gastrointestinal digestion and cyclodextrin encapsulation. Molecules, 25 (12), 5027, 15 doi:10.3390/molecules25215027.
@article{article, author = {Radi\'{c}, Kristina and Vinkovi\'{c} Vr\v{c}ek, Ivana and Pavi\v{c}i\'{c}, Ivan and Vitali \v{C}epo, Dubravka}, year = {2020}, pages = {15}, DOI = {10.3390/molecules25215027}, chapter = {5027}, keywords = {olive pomace extract, cyclodextrin, in vitro gastrointestinal digestion, antioxidant}, journal = {Molecules}, doi = {10.3390/molecules25215027}, volume = {25}, number = {12}, issn = {1420-3049}, title = {Cellular antioxidant activity of olive pomace extracts: impact of gastrointestinal digestion and cyclodextrin encapsulation}, keyword = {olive pomace extract, cyclodextrin, in vitro gastrointestinal digestion, antioxidant}, chapternumber = {5027} }
@article{article, author = {Radi\'{c}, Kristina and Vinkovi\'{c} Vr\v{c}ek, Ivana and Pavi\v{c}i\'{c}, Ivan and Vitali \v{C}epo, Dubravka}, year = {2020}, pages = {15}, DOI = {10.3390/molecules25215027}, chapter = {5027}, keywords = {olive pomace extract, cyclodextrin, in vitro gastrointestinal digestion, antioxidant}, journal = {Molecules}, doi = {10.3390/molecules25215027}, volume = {25}, number = {12}, issn = {1420-3049}, title = {Cellular antioxidant activity of olive pomace extracts: impact of gastrointestinal digestion and cyclodextrin encapsulation}, keyword = {olive pomace extract, cyclodextrin, in vitro gastrointestinal digestion, antioxidant}, chapternumber = {5027} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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