Naslov
Ultrastructure of photoreceptors after cultivation at an ectopic place

Autori
Himelreich M, Lekić M

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Catalogue of 8th International Fair of Innovations, New Products and Technologies ARCA / - , 2010, 88-89

Skup
8th International Fair of Innovations, New Products and Technologies ARCA

Mjesto i datum
Zagreb, Hrvatska, 30.09.2010. - 02.10.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
photoreceptors, rat, in vivo

Sažetak
Investigations of the developmental potential of different eye structures such as the retina are important in designing novel approaches to tissue replacement therapy aimed to cure damaged parts of the eye. The purpose of here presented experiments was to further investigate the developmental potential of the fetal rat retina cultivated in vitro or transplanted in vivo at an ectopic site. By this study we confirmed our hypothesis that fetal neural retina of the rat can survive in vitro in a three-dymensional organ culture model in serum supplemented and chemically defined culture medium, although the normal tissue architecture is lost. However, retinal cells seem to have retained their typical morphology and even the physiological process of photoreceptor outer segment shedding could take place. Rat fetal retina survived in ectopic transplants in vivo for 120 days which was two and half months more than we previously described.

Izvorni jezik
Engleski

POVEZANOST RADA