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Pregled bibliografske jedinice broj: 1087937

Antioxidant ameliorated negative impact of a DNA- demethylating agent on placental growth and morphology of aged preterm placentas

Sobočan, Nikola; Katušić-Bojanac, Ana; Sinčić, Nino; Himelreich, Marta; Krasić, Jure; Majić, Željka; Jurić-Lekić, Gordana; Šerman, Ljiljana; Vlahović, Maja; Marić, Andreja et al.
Antioxidant ameliorated negative impact of a DNA- demethylating agent on placental growth and morphology of aged preterm placentas // Liječnički vjesnik : glasilo Hrvatskog liječničkog zbora. Suplement, 142 (2020), 1 / Kujundžić Tiljak, Mirjana ; Reiner, Željko ; Klarica, Marijan ; Anić, Branimir ; Borovečki, Ana (ur.).
Zagreb: Hrvatski liječnički zbor, 2020. str. 36-37 doi:10.26800/LV-142-Suppl1-2 (predavanje, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 1087937 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Antioxidant ameliorated negative impact of a DNA- demethylating agent on placental growth and morphology of aged preterm placentas

Autori
Sobočan, Nikola ; Katušić-Bojanac, Ana ; Sinčić, Nino ; Himelreich, Marta ; Krasić, Jure ; Majić, Željka ; Jurić-Lekić, Gordana ; Šerman, Ljiljana ; Vlahović, Maja ; Marić, Andreja ; Ježek, Davor ; Bulić-Jakuš, Floriana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Liječnički vjesnik : glasilo Hrvatskog liječničkog zbora. Suplement, 142 (2020), 1 / Kujundžić Tiljak, Mirjana ; Reiner, Željko ; Klarica, Marijan ; Anić, Branimir ; Borovečki, Ana - Zagreb : Hrvatski liječnički zbor, 2020, 36-37

Skup
BFHA2020 Better Future of Healthy Ageing

Mjesto i datum
Zagreb, Hrvatska; online; konferencija, 03.06.2020. - 05.06.2020

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
DNA methylation ; 5azaC ; placenta ; rat

Sažetak
We showed that a DNA demethylating agent/epigenetic drug 5 azacytidine (5azaC) used in treatment of human malignancies is a teratogen that impaired growth of both embryos and placentas in treated rat dams. The pretreatment with the antioxidant N tert Butyl α phenylnitron (PBN) improved development of rat fetuses. We now investigated whether pretreatment with the antioxidant PBN could improve the placental development/ aging in 5 azaC treated pregnant dams. 12 th and 13 th days of gestation: endovascular trophoblast invasion and intense proliferation of the labyrinth and basal zone. 20 th day of gestation: basal zone regresses and labyrinth fully develops. Conclusion: In preterm placentas (20 days old) PBN pretreatment significantly rescued growth diminished by 5 azaC through lowering the number of apoptotic cells that was associated with a significantly lower amount of cells under oxidative nitrosative stress. DNA demethylating epigenetic drug induces oxidative nitrosative stress in the aged placentas. Because DNA demethylation causing oxidative stress might also be of importance for placental premature aging during human gestation leading to IUGR, we propose further investigation of the antioxidant PBN profilactic activity for the prevention of IUGR.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Klinička bolnica "Merkur",
Medicinski fakultet, Zagreb

Profili:

Avatar Url Maja Vlahović (autor)

Avatar Url Gordana Jurić-Lekić (autor)

Avatar Url Davor Ježek (autor)

Avatar Url Ljiljana Šerman (autor)

Avatar Url Marta Himelreich Perić (autor)

Avatar Url Jure Krasić (autor)

Avatar Url Nikola Sobočan (autor)

Avatar Url Floriana Jakuš (autor)

Avatar Url Nino Sinčić (autor)

Avatar Url Ana Katušić Bojanac (autor)

Poveznice na cjeloviti tekst rada:

doi hrcak.srce.hr

Citiraj ovu publikaciju:

Sobočan, Nikola; Katušić-Bojanac, Ana; Sinčić, Nino; Himelreich, Marta; Krasić, Jure; Majić, Željka; Jurić-Lekić, Gordana; Šerman, Ljiljana; Vlahović, Maja; Marić, Andreja et al.
Antioxidant ameliorated negative impact of a DNA- demethylating agent on placental growth and morphology of aged preterm placentas // Liječnički vjesnik : glasilo Hrvatskog liječničkog zbora. Suplement, 142 (2020), 1 / Kujundžić Tiljak, Mirjana ; Reiner, Željko ; Klarica, Marijan ; Anić, Branimir ; Borovečki, Ana (ur.).
Zagreb: Hrvatski liječnički zbor, 2020. str. 36-37 doi:10.26800/LV-142-Suppl1-2 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Sobočan, N., Katušić-Bojanac, A., Sinčić, N., Himelreich, M., Krasić, J., Majić, Ž., Jurić-Lekić, G., Šerman, L., Vlahović, M. & Marić, A. (2020) Antioxidant ameliorated negative impact of a DNA- demethylating agent on placental growth and morphology of aged preterm placentas. U: Kujundžić Tiljak, M., Reiner, Ž., Klarica, M., Anić, B. & Borovečki, A. (ur.)Liječnički vjesnik : glasilo Hrvatskog liječničkog zbora. Suplement, 142 (2020), 1 doi:10.26800/LV-142-Suppl1-2.
@article{article, author = {Sobo\v{c}an, Nikola and Katu\v{s}i\'{c}-Bojanac, Ana and Sin\v{c}i\'{c}, Nino and Himelreich, Marta and Krasi\'{c}, Jure and Maji\'{c}, \v{Z}eljka and Juri\'{c}-Leki\'{c}, Gordana and \v{S}erman, Ljiljana and Vlahovi\'{c}, Maja and Mari\'{c}, Andreja and Je\v{z}ek, Davor and Buli\'{c}-Jaku\v{s}, Floriana}, year = {2020}, pages = {36-37}, DOI = {10.26800/LV-142-Suppl1-2}, keywords = {DNA methylation, 5azaC, placenta, rat}, doi = {10.26800/LV-142-Suppl1-2}, title = {Antioxidant ameliorated negative impact of a DNA- demethylating agent on placental growth and morphology of aged preterm placentas}, keyword = {DNA methylation, 5azaC, placenta, rat}, publisher = {Hrvatski lije\v{c}ni\v{c}ki zbor}, publisherplace = {Zagreb, Hrvatska; online; konferencija} }
@article{article, author = {Sobo\v{c}an, Nikola and Katu\v{s}i\'{c}-Bojanac, Ana and Sin\v{c}i\'{c}, Nino and Himelreich, Marta and Krasi\'{c}, Jure and Maji\'{c}, \v{Z}eljka and Juri\'{c}-Leki\'{c}, Gordana and \v{S}erman, Ljiljana and Vlahovi\'{c}, Maja and Mari\'{c}, Andreja and Je\v{z}ek, Davor and Buli\'{c}-Jaku\v{s}, Floriana}, year = {2020}, pages = {36-37}, DOI = {10.26800/LV-142-Suppl1-2}, keywords = {DNA methylation, 5azaC, placenta, rat}, doi = {10.26800/LV-142-Suppl1-2}, title = {Antioxidant ameliorated negative impact of a DNA- demethylating agent on placental growth and morphology of aged preterm placentas}, keyword = {DNA methylation, 5azaC, placenta, rat}, publisher = {Hrvatski lije\v{c}ni\v{c}ki zbor}, publisherplace = {Zagreb, Hrvatska; online; konferencija} }

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