Naslov
Comprehensive study on molybdenum(VI) complexes of 3-methoxysalicylaldehyde isonicotinoylhydrazone

Autori
Mandarić, Mirna ; Cvijanović, Danijela ; Prugovečki, Biserka ; Kekez, Ivana ; Vrdoljak, Višnja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
Chemistry Conference for Young Scientists 2020

Mjesto i datum
Blankenberge, Belgija, 19.02.2020. - 21.02.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
molybdenum(VI) complexes ; hydrazone ; solid state transformations ; citotoxicity

Sažetak
During the past few decades there has been an increasing interest towards the studies of the coordination compounds containing the hydrazone moiety due to their numerous biological activities (e.g. antifungal, antibacterial, antitumor, anti- inflammatory, antipyretic). Moreover, these complexes have been reported as analytical reagents, fluorescent materials and corrosion inhibitors.[1] The presented study examines the formation of various complexes containing cis-MoO2 2+ and 3- methoxysalicylaldehyde isonicotinoylhydrazone (H2L) moieties, and the factors that affect their formation. The conventional solution- based synthetic procedures included the selected aroylhydrazone ligand and [MoO2(acac)2], [MoO2Cl2] or [MoO2Br2(dmf)2] as starting Mo(VI) complex in dry methanol or acetonitrile. Depending on the reaction conditions, complexes [MoO2(L)(MeOH)], [MoO2(HL) (MeOH)]X (X = Cl or Br) and [MoO2(L)]n were attained. Also, specific synthetic procedures led to the formation of cocrystals of [MoO2(HL) (MeOH)]X·H2L' (X = Cl or Br), where H2L' represents the in situ produced 3- methoxysalicylaldehyde azine. All synthesized compounds were characterized by elemental analysis, thermogravimetric analysis, IR spectroscopy, 1D and 2D NMR spectroscopy and powder X-ray diffraction. Single-crystal X-ray diffraction method was used to determine the crystal and molecular structures. In addition to the conventional solution-based methods, solid- state transformations were also explored. Finally, the cytotoxicity of complexes was evaluated against THP-1 and HepG2 cells while their antibacterial activity was assessed against S. aureus, E. faecalis, E. coli and M. catarrhalis by broth microdilution.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA