Pregled bibliografske jedinice broj: 1085444
Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis
Differential Expression of TFF1 and TFF3 in Patients Suffering from Chronic Rhinosinusitis with Nasal Polyposis // International journal of molecular sciences, 20 (2019), 21; 5461, 15 doi:10.3390/ijms20215461 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1085444 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Differential Expression of TFF1 and TFF3 in
Patients Suffering from Chronic Rhinosinusitis
with Nasal Polyposis
Autori
Mihalj, Martina ; Bujak, Maro ; Butković, Josip ; Zubčić, Željko ; Tolušić Levak, Maja ; Čes, Josip ; Kopić, Vlatko ; Baus Loncar, Mirela ; Mihalj, Hrvoje
Izvornik
International journal of molecular sciences (1422-0067) 20
(2019), 21;
5461, 15
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
kronični rinosinusitis ; nosna polipoza ; trefoil factor family proteni
(chronic rhinosinusitis ; nasal polyposis ; trefoil factor family)
Sažetak
Trefoil family factor (TFF) proteins contribute to antimicrobial defense and the maintenance of sinonasal epithelial barrier integrity. Dysregulation of TFF expression may be involved in the development of chronic inflammation and tissue remodeling characteristically found in chronic rhinosinusitis with nasal polyposis (CRSwNP). Expressions of TFF1 and TFF3 were determined in specimens of middle nasal turbinate (MNT-0), bulla ethmoidalis (BE), and nasal polyps (NP) from CRSwNP patients (n = 29) and inferior nasal turbinate from a group of control patients (underwent nasal septoplasty, n = 25). An additional MNT sample was collected 6 months after functional endoscopic sinus surgery (FESS, MNT-6). TFF1 mRNA levels were significantly reduced in all specimens by approximately three- to five-fold, while TFF3 was increased in MNT-0, as compared with controls. Six months after surgery their levels were reversed to control values. CRSwNP patients with S. epidermidis isolated from sinus swabs showed upregulation of TFF3 in MNT and NP as compared with patients with sterile swabs. Target gene regulation was not affected by the presence of type 2 inflammation in patients with confirmed allergy. Results of this study imply participation of TFFs genes in the development of CRSwNP.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Dentalna medicina
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-2717 - TFF3 protein na raskrižju metabolizma i neurodegeneracije (Inter MeNe-3) (Baus Lončar, Mirela, HRZZ - 2016-06) ( CroRIS)
MZOS-219-0982914-2179 - Uloga malih zaštitinih TFF proteina u zdravlju i bolesti (Belovari, Tatjana, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek,
Sveučilište J. J. Strossmayera u Osijeku
Profili:
Željko Zubčić
(autor)
Mirela Baus Lončar
(autor)
Maro Bujak
(autor)
Maja Tolušić Levak
(autor)
Hrvoje Mihalj
(autor)
Vlatko Kopić
(autor)
Martina Mihalj
(autor)
Josip Butković
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE