Naslov
Farmakogenomika hipolipemika: ABCG2 kao mogući prediktor hepatotoksičnosti
(The pharmacogenomics of hypolipemics: ABCG2 as a potential predictor of hepatotoxicity)

Autori
Božina, Nada ; Šimičević, Livija ; Pećin, Ivan ; Božina, Tamara ; Reiner, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biochemia medica, 28 (2018), Suppl 1 / Pašalić, Daria - Zagreb : Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu (HDMBLM) ; Medicinska naklada, 2018, S190-S191

Skup
9. kongres hrvatskog društva za medicinsku biokemiju i laboratorijsku medicinu (HDMBLM)

Mjesto i datum
Zagreb, Hrvatska, 09.05.2018. - 12.05.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
pharmacogenomics ; hypolipemics ; ABCG2

Sažetak
The ABCG2 protein is an active drug transporter across biological barriers, playing an important role in pharmacokinetics. Located on the intestinal, kidney and hepatic epithelial cells membranes, it enables substrate transport to the organ’s luminal side, acting as an efflux pump. Many drugs, known to be substrates/inhibitors of ABCG2, are recognized to be a relevant factor for the development of drug interactions and adverse events. The ABCG2 gene is polymorphic and its variant 421C>A, responsible for low activity, is presentin ~15% of Caucasians.

Izvorni jezik
Hrvatski, engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA