Naslov
Reader's Comment on Meta-analysis of C-Reactive Protein and Risk of Angina Pectoris

Autori
Fabijanic, Damir ; Luksic, Bruno ; Ljubkovic, Marko

Izvornik
The American journal of cardiology (0002-9149) 128 (2020); 160-160

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, stručni

Ključne riječi
C reactive Protein

Sažetak
We would like to highlight that CRP is primarily an indicator of augmented inflammatory status, which is an active promotor of atherogenesis and trigger of acute coronary syndromes. Inflammatory process causing elevated CRP, even when primarily located outside of the cardiovascular system, can still promote atherosclerosis through a number of proatherogenic and prothrombotic mechanisms. Therefore, patients in whom elevated CRP indicates higher inflammatory risk also require very intensive management of CV status (e.g. intensification of statin therapy). In patients with very high hs-CRP levels (>10 mg/L), as was noted in some of the studies included in this meta-analysis, other causes of chronic systemic inflammation should be considered because their healing can additionally reduce systemic inflammatory risk, the progression of CAD and the onset of MACE.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA