Naslov
Sinteza novih N-heterocikličkih derivata 1,1'- disupstituiranih ferocena primjenom mehanokemije i eutektičkih otapala
(Synthesis of new N-heterocycle 1,1’-disubstituted ferrocene conjugates using mechanochemistry and deep eutectic solvents)

Autori
Maračić, Silvija ; Piškor, Martina ; Čipor, Ivona ; Lapić, Jasmina ; Djaković, Senka ; Raić-Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
BOOK OF ABSTRACTS / Jukić, Ante ; Ocelić Bulatović, Vesna ; Kučić Grgić, Dajana - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2020, 38-38

Skup
18. Ružičkini dani "Danas znanost - sutra industrija"

Mjesto i datum
Vukovar, Hrvatska, 16.09.2020. - 18.09.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
ferocen, 1, 2, 3-triazol, mehanokemija, eutektička otapala
(ferrocene, 1, 2, 3-triazole, mechanochemistry, deep eutectic solvents)

Sažetak
In recent years, medicinal chemistry has faced a significant evolution in both approaches and methodologies because of the advent of new and innovative technologies. In this context, mechanochemistry does not only provide an access to reactivity of materials that are difficult or even impossible to reach from solution, but fulfils the demands of pharmaceutical industry for greener and more efficient alternative to a majority of conventional transformations [1, 2]. On the other hand, the use of deep eutectic solvents (DESs), as alternative environmentally benign solvents for organic synthesis, have found increased attention because of their high thermal stability, non- flammability and practically no vapour pressure [3]. Novel conjugates of purine, purine bioisosteres and 1, 1’-disubstituted ferrocenes were synthesized using Cu(I) catalysed 1, 3- dipolar cycloaddition reaction in sorbitol/urea/NH4Cl deutectic mixture, while 1, 1’-disubstituted ferrocene quinoline derivatives bridged via 1, 2, 3-triazole unit were prepared under solvent-free mechanochemical conditions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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