Naslov
Effects of dopaminergic drugs on inflammatory bowel disease induced with 2, 4- dinitrofluorbenzene in BALB/c mice
(Effects of dopaminergic drugs on inflammatory bowel disease induced with 2, 4-dinitrofluorbenzene in BALB/c mice)

Autori
Herak-Perković, Vlasta ; Grabarević, Željko ; Banić, Marko ; Anić, Branimir ; Novosel, Vesna ; Pogačnik, Milan

Izvornik
Journal of veterinary pharmacology and therapeutics (0140-7783) 24 (2001), 4; 267-273

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
induced gastric-ulcers ; therapeutic applications ; animal-model ; agonists ; rats ; stomach ; bromocriptine

Sažetak
The aim of the study was to demonstrate the effects of dopaminergic drugs on 2, 4- dinitrofluorbenzene (DNFB) induced experimental inflammatory bowel disease (IBD) in previously sensitised BALB/c mice. The number and extent of ulcerations and erosions, the intensity of haeomorrhages, edema, and accumulation of neutrophils and eosinophils within colonic lamina propria and submucosa were scored and statistically evaluated. The 180 BALB/c mice, were allocated into three equal groups. The mice in the first experimental group were treated with domperidone (DP), a peripheral dopamine (DA) antagonist. The mice from the second experimental group were treated with bromocriptine (BC), a dopamine agonist. The mice from the control group were treated with an equivalent volume of normal saline in the same manner. Ten animals from each group were killed on days 1, 2, 3, 5, and 10, subsequent to the challenge enema of the DNFB solution. Gross and microscopic examination of the colon was performed. Treatment with BC resulted in clinical improvement and decreased mortality rate by 2 of 60 (3%), while domperidone treatment increased mortality rate to 12 of 60 (20%) compared with the controls (4 of 60 /6%/). The nalysis of the microscopic lesions indicated that the beneficial effects of BC were the result of maintenance of vascular integrity.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA