Naslov
Involvement of T lymphocytes in the placentae with villitis of unknown etiology from pregnancies complicated with preeclampsia

Autori
Benzon, Sandra ; Zekić Tomaš, Sandra ; Benzon, Zdeslav ; Vulić, Marko ; Kuzmić Prusac, Ivana

Izvornik
The Journal of Maternal-Fetal & Neonatal Medicine (1476-7058) 29 (2015), 7; 1055-1060

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Preeclampsia, T lymphocytes, villitis of unknown etiology

Sažetak
Translator disclaimer Abstract Objective: The aim of the study was to compare immunohistochemical expression of different T type lymphocytes in foci of villitis of placentae with villitis of unknown etiology (VUE) without and with preeclampsia (PE). Methods: Fifty-four placentae were collected from women who had VUE with (N = 27) and without (N = 27) PE. Immunohistochemistry for types of T lymphocytes was performed on formalin fixed and paraffin-embedded sections by use of the CD3, CD4, FOXP3, CD25, CD8 and CD68 antibodies. All data analyses were done by R Development Core Team. Results: There was higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE compared to control group. Conclusion: The higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE could point to their role in ethiopathogenesis of PE.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA