Naslov
The effects of n-3 PUFAs enriched chicken eggs' consumption on biochemical markers of microvascular function in human subjects

Autori
Drenjančević, Ines ; Stupin, Ana ; JUkic, Ivana ; Stupin, Marko ; Kibel, Aleksandar ; Selthofer-Relatić, Kristina ; Mihalj, Martina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, ostalo

Skup
The 14th Annual Symposium of the Croatian Physiological Society with international participation „Homeostasis – From Cell to Organ“ September 25th – 26th, 2020 „online“ MS Teams

Mjesto i datum
Hrvatska, 25.09.2020. - 26.09.2020

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
microvascular reactivity ; n-3 PUFAs ; acetylcholine ; endothelium

Sažetak
Introduction: n-3 polyunsaturated fatty acids (n-3 PUFAs) have the potential to prevent development and progression of various (CV) diseases, including atherosclerosis and atherosclerosis related diseases, in part, by improving vascular (endothelial) function as demonstrated in numerous epidemiological and clinical trials. Aim: Present study aimed to examine the effects of n-3 PUFAs enriched hen eggs consumption on microvascular function of healthy young individuals (age 24±2 yrs) of both sexes, before and 3 weeks after standard eggs' consumption (control group, n=21) and n-3 PUFAs enriched eggs (experimental group, n=19). Materials and Methods: The subjects consumed three boiled eggs daily for three weeks, the total amount of n-3 PUFA per day was 249 mg for the control group, and for the experimental group 1053 mg n-3PUFA / day. Lipid profile, hsCRP were measured from blood samples. Microvascular reactivity was determined by Laser Doppler Flowmetry, before and after dietary protocol. Statistical analysis was conducted by t-test (between groups) and paired t-test (within the group comparisons) ; statistical significance was set as p<0.05. Study was approved by Ethical Committee of Scientific Centre of Excellence, and all participants gave written informed consent. Results: Participants on n-3 PUFAs eggs had significanlty lower cholesterol and higher HDL-cholesterol after dietary protocol compared to control group and slightly higher LDL-cholesterol, compared to their starting values. Control participants had significanlty higher body fat %, without changes in body mass indeks (BMI). Systolic and mean arterial blood pressure decreased in control subjects after dietary protocol. Subject in experimental group did not have changes in arterial blood pressure, BMI or body tissue composition. Microvascular flow was significantly increased after n-3 PUFAs consumption (acetylcholine-induced dilation). Conclusions: n-3 PUFAs enriched eggs' consumption can affect biochemical values and improve endothelium-dependent vascular function even in young, healthy subjects.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
The study was supported by European Structural and Investment Funds through a grant to the Croatian National Science Center of Excellence for Personalized Health Care, Josip Juraj Strossmayer University of Osijek # KK.01.1.1.01.0010.

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