Naslov
Expression of activated microglia cells markers IBA1, CD68, and HLA-DR in the hippocampal formation of patients with Alzheimer's disease

Autori
Španić, Ena ; Ilić, Katarina ; Babić Leko, M ; Langer Horvat, Lea ; Šimić, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
9th Croatian Congress of Pharmacology with International Participation Book of Abstracts / - , 2019, 124-124

Skup
9. hrvatski kongres farmakologije = 9th Croatian Congress of Pharmacology

Mjesto i datum
Zagreb, Hrvatska, 25.09.2019. - 28.09.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Alzheimer's disease ; hippocampal formation ; microglia ; neuroinflammation ; pro-inflammatory markers

Sažetak
Numerous studies have documented that uncontrolled immune response in the brain contributes to the progression of Alzheimer's disease (AD). The main goal of this study was to analyzed the expression of microglia cells markers IBA1, CD68, and HLA-DR in the different areas of the hippocampal formation (granular cell layer of dentate gyrus, hilus, CA2/3, CA1, subiculum, and white matter) of patients with AD and control samples. The results showed positive correlation between the expression of activated microglia cells markers CD68 and HLA-DR with AD. However, IBA1 was negatively correlated with AD. These results support the inflammatory hypothesis of AD and suggest that the aberrant microglial response might be crucial for the development and progression of all neuropathological changes seen in AD.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)

POVEZANOST RADA