Naslov
Dissolution kinetics of copper nanoparticles in model physiological fluids and dynamics of copper(II) complexes with chiral amino acids
(Dissolution kinetics of copper nanoparticles in model physiological fluids and dynamics of copper(ii) complexes with chiral amino acids)

Autori
Jurković, Lara ; Hazdovac, Ivana ; Maltar-Strmečki, Nadica ; Mark Lyons, Daniel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Adriatic NMR: Book of Abstract / - , 2020, 40-40

Skup
Adriatic NMR

Mjesto i datum
Peroj, Hrvatska, 22.09.2020. - 24.09.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
EPR ; copper nanoparticles ; kinetics ; amino acids

Sažetak
Metallic nanoparticles have attracted huge attention in biomedical applications due to their unique size-dependent properties, in particular copper nanoparticles because of their anti-bacterial, anti-fungal, anti- inflammatory and anti-proliferative properties [1]. However, the potential for interactions with non-targeted healthy cells, especially as copper nanoparticles may undergo a range of chemical transformations in the body, represents a still unresolved issue. In particular, the quantity and rate of copper nanoparticle dissolution in bodily fluids and tissue, with release of ionic Cu2+, may represent a key step in the pharmacokinetics and potential toxicity of such nanomaterials. Thus, we report herein an analysis of the physicochemical properties and dissolution kinetics of copper nanoparticles in saline solution in the presence of bovine serum albumin as a simplified model for blood plasma. Further, as copper(II) complexes with amino acids serve as models for metalloproteins and transport in a wide range of important biological processes, we have subsequently investigated the nanoparticle-released Cu2+ in terms of the dynamical behavior of copper(II) bis-complexes with selected chiral amino acids (nonpolar, polar and electrically charged). The complexes were studied by electron paramagnetic resonance (EPR) spectroscopy with the presence of the cis and trans isomers determined for both L- and D- enantiomers [2]. The influence of this chirality on the rotational motion of the Cu(II)-amino acid complexes was also examined. These results will help in resolving transformation pathways, behaviour and safety of metallic nanoparticles in physiological fluids as their application in biomedicine becomes more widespread.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija, Interdisciplinarne prirodne znanosti, Interdisciplinarne biotehničke znanosti

POVEZANOST RADA