Naslov
Sinteza i antioksidativna aktivnost novih karboksamida N-supstituiranih benzimidazola
(Synthesis and antioxidative activity of novel N- substituted benzimidazole carboxamides)

Autori
Beč, Anja ; Kos, Marija ; Debogović Patricia ; Hranjec, Marijana ; Starčević, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
BOOK OF ABSTRACTS 18th Ružička Days TODAY SCIENCE – TOMORROW INDUSTRY / Jukić, Ante ; Ocelić Bulatović, Vesna ; Kučić Grgić, Dajana - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2020, 126-126

ISBN
978-953-6894-75-8

Skup
18. Ružičkini dani "Danas znanost - sutra industrija"

Mjesto i datum
Vukovar, Hrvatska, 16.09.2020. - 18.09.2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
amidi, antioksidativna aktivnost, benzimidazoli, karboksamidi, organska sinteza
(amides, antioxidative activity, benzimidazoles, carboxamides, organic synthesis)

Sažetak
A variety of biochemical processes in the human body could produce oxygen free radicals and other reactive oxygen species (ROS) as by- products which may cause oxidative damage of most important biomolecules such as nucleic acids, lipids and proteins. There has been tremendous and constant growing interest for the searching of novel natural or synthetic organic molecules as potential antioxidants. Heterocycles like benzimidazole derivatives can be promising candidates as antioxidants as these compounds are reported to exhibit a wide range of biological activity [1]. In this work, we present the synthesis of a range of N-substituted benzimidazole-2- carboxamides with a variable number of methoxy groups using conventional organic synthetic methods. Starting from the corresponding benzoyl-chlorides, in the reaction with N-substituted 2-aminobenzimidazoles carboxamides were obtained in moderate reaction yields [2]. Their antioxidative potency has been evaluated using 1, 1-diphenyl-picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) assays.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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