Naslov
Plasma levels of interleukin-6 in response to two different techniques of postoperative analgesia

Autori
Kristek, Gordana ; Radoš, Ivan ; Kristek, Dalibor ; Škiljić, Sonja ; Nešković, Nenad ; Vinković, Hrvoje ; Haršanji-Drenjančević, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts / - Zagreb, 2019, 30-30

Skup
7th Croatian Congress on Regional Anaesthesia and Analgesia with International Participation

Mjesto i datum
Zagreb, Hrvatska, 14.06.2019. - 15.06.2019

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
patient-controlled analgesia ; elderly ; femoral fractures ; IL-6

Sažetak
Background and purpose: To compare the effect of two different anesthetic techniques, epidural patient-controlled analgesia (PCEA) using 0.125% levobupivacaine and intravenous patient-controlled analgesia (PCIA) with morphine on plasma interleukine-6 (IL-6) levels and to determine whether the IL-6 is related to postoperative cognitive dysfunction (POCD). Materials and methods: Randomized, prospective, controlled study in an academic hospital. Patients were ≥ 65 years old, scheduled for the femoral fracture fixation from July 2016 to September 2017. Plasma IL-6 concentration was assessed in 3 blood samples (before anesthesia, 24h and 72h postoperatively). Cognitive functions were assessed using Mini-Mental State Examination (MMSE) preoperatively, from the 1st to the 5th postoperative day and on the day of discharge. Analgesia was assessed by Numerical Rating Scale (NRS) every 3 hours after surgery for 72 hours. Results: Study population included 70 patients, 35 in each group. The incidence of POCD was significantly lower in the PCEA group (9%) than in the PCIA group (31%) (p=0, 03). IL-6 values were significantly lower in the PCEA group 72h after surgery (p=0, 02). The only predictor of POCD in all patients was level of IL-6 72h after surgery (p=0, 03). The NRS pain scores were significantly lower in the PCEA group at all postoperative time points. Conclusions: Postoperative PCEA using 0.125% levobupivacaine provides better pain relief and reduces the incidence of POCD compared to PCIA with morphine in studied population. IL-6 might serve as an indicator to guide the prevention and treatment of POCD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA