Naslov
Cell membrane‐related toxic responses and disruption of intercellular communication in PCB mechanisms of toxicity: A review

Autori
Murati, Teuta ; Miletić, Marina ; Pleadin, Jelka ; Šimić, Branimir ; Kmetič, Ivana

Izvornik
JAT. Journal of applied toxicology (0260-437X) 40 (2020), 12; 1592-1601

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cell membrane, connexins, gap junction intercellular communication, PCB, polychlorinated biphenyls, tight junction

Sažetak
An understanding of polychlorinated biphenyl (PCB) congener-specific effects on cell membrane and intercellular communication is important within the studies of PCB absorption, organ-related PCB accumulation and exertion of toxic responses. Toxic potential of PCBs is linked to various deleterious effects on human health, including neu- rotoxicity, immunotoxicity, reproductive toxicity and genotoxicity and, recently in 2016 International Agency for Research on Cancer (IARC) has upgraded the classification of PCBs to Group 1 “Carcinogenic to humans.” Proposed mechanisms of aforementioned PCBs adverse effects at cellular membrane level are: (i) downregulation of gap junction intercellular communication and/or connexins ; (ii) compromised membrane integrity ; and (iii) altered tight junction barrier function. This study, based on an extensive literature survey, shows the progress in scientific research of each of these three levels with the aim of pointing out the earliest toxic events of PCBs, which can result in serious cell/tissue/organ damage.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA