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Pregled bibliografske jedinice broj: 1077332

Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia


Banovac, Ivan; Sedmak, Dora; Rojnić Kuzman, Martina; Hladnik, Ana; Petanjek, Zdravko
Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia // Croatian medical journal, 61 (2020), 4; 354-365 doi:10.3325/cmj.2020.61.354 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1077332 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia

Autori
Banovac, Ivan ; Sedmak, Dora ; Rojnić Kuzman, Martina ; Hladnik, Ana ; Petanjek, Zdravko

Izvornik
Croatian medical journal (0353-9504) 61 (2020), 4; 354-365

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rapid Golgi staining, prefrontal cortex, pyramidal neurons, schizophrenia, axon impregnation

Sažetak
Aim To analyze axon morphology on rapid Golgi impregnated pyramidal neurons in the dorsolateral prefrontal cortex in schizophrenia. Methods Postmortem brain tissue from five subjects diagnosed with schizophrenia and five control subjects without neuropathological findings was processed with the rapid Golgi method. Layer III and layer V pyramidal neurons from Brodmann area 9 were chosen in each brain for reconstruction with Neurolucida software. The axons and cell bodies of 136 neurons from subjects with schizophrenia and of 165 neurons from control subjects were traced. The data obtained by quantitative analysis were compared between the schizophrenia and control group with the t test. Results Axon impregnation length was consistently greater in the schizophrenia group. The axon main trunk length was significantly greater in the schizophrenia than in the control group (93.7 ± 36.6 μm vs 49.8 ± 9.9 μm, P = 0.032). Furthermore, in the schizophrenia group more axons had visibly stained collaterals (14.7% vs 5.5%). Conclusion Axon rapid Golgi impregnation stops at the beginning of the myelin sheath. The increased axonal staining in the schizophrenia group could, therefore, be explained by reduced axon myelination. Such a decrease in axon myelination is in line with both the disconnection hypothesis and the two-hit model of schizophrenia as a neurodevelopmental disease. Our results support that the cortical circuitry disorganization in schizophrenia might be caused by functional alterations of two major classes of principal neurons due to altered oligodendrocyte development.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
--UIP-2014-09-1245 - Biomarkeri u shizofreniji – integracija komplementarnih prisutupa u praćenju osoba s prvom psihotičnom epizodom (BIS – LF FEP) (Rojnić Kuzman, Martina) ( CroRIS)
--IP-2013-11-5943 - Neuralna osnova viših spoznajnih funkcija (COGNITIVECIRCUIT) (Petanjek, Zdravko) ( CroRIS)
--KK.01.1.1.01.0007 - Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi (ZCI Neuro) (Judaš, Miloš) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi www.cmj.hr pubmed.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

Banovac, Ivan; Sedmak, Dora; Rojnić Kuzman, Martina; Hladnik, Ana; Petanjek, Zdravko
Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia // Croatian medical journal, 61 (2020), 4; 354-365 doi:10.3325/cmj.2020.61.354 (međunarodna recenzija, članak, znanstveni)
Banovac, I., Sedmak, D., Rojnić Kuzman, M., Hladnik, A. & Petanjek, Z. (2020) Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia. Croatian medical journal, 61 (4), 354-365 doi:10.3325/cmj.2020.61.354.
@article{article, author = {Banovac, Ivan and Sedmak, Dora and Rojni\'{c} Kuzman, Martina and Hladnik, Ana and Petanjek, Zdravko}, year = {2020}, pages = {354-365}, DOI = {10.3325/cmj.2020.61.354}, keywords = {rapid Golgi staining, prefrontal cortex, pyramidal neurons, schizophrenia, axon impregnation}, journal = {Croatian medical journal}, doi = {10.3325/cmj.2020.61.354}, volume = {61}, number = {4}, issn = {0353-9504}, title = {Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia}, keyword = {rapid Golgi staining, prefrontal cortex, pyramidal neurons, schizophrenia, axon impregnation} }
@article{article, author = {Banovac, Ivan and Sedmak, Dora and Rojni\'{c} Kuzman, Martina and Hladnik, Ana and Petanjek, Zdravko}, year = {2020}, pages = {354-365}, DOI = {10.3325/cmj.2020.61.354}, keywords = {rapid Golgi staining, prefrontal cortex, pyramidal neurons, schizophrenia, axon impregnation}, journal = {Croatian medical journal}, doi = {10.3325/cmj.2020.61.354}, volume = {61}, number = {4}, issn = {0353-9504}, title = {Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia}, keyword = {rapid Golgi staining, prefrontal cortex, pyramidal neurons, schizophrenia, axon impregnation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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