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Pregled bibliografske jedinice broj: 1076414

Stratum corneum biomarkers in atopic dermatitis: biological and spatial variability


Jurakić Tončić, Ružica; Kežić, Sanja; Ljubojević Hadžavdić, Suzana; Marinović, Branka; Jakaša, Ivone
Stratum corneum biomarkers in atopic dermatitis: biological and spatial variability // The Open biomarkers journal, 10 (2020), 47-54 doi:10.2174/1875318302010010047 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1076414 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Stratum corneum biomarkers in atopic dermatitis: biological and spatial variability

Autori
Jurakić Tončić, Ružica ; Kežić, Sanja ; Ljubojević Hadžavdić, Suzana ; Marinović, Branka ; Jakaša, Ivone

Izvornik
The Open biomarkers journal (1875-3183) 10 (2020); 47-54

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
atopic dermatitis ; biomarkers ; non-invasive ; cytokines ; filaggrin ; stratum corneum

Sažetak
Background: Atopic dermatitis is a highly heterogeneous skin disease, mainly affecting children. Introduction of biological therapies has urged the development of biomarkers to facilitate personalized therapy. Stratum corneum biomarkers emerged as a promising non-invasive alternative to skin biopsy, yet validation of spatial and biological variability is essential for their application in clinical research. Objective: To assess spatial and biological variability of stratum corneum biomarkers for atopic dermatitis. Methods: Stratum corneum was collected from 17 atopic dermatitis patients by consecutive application of eight adhesive tapes to a lesional skin site and 2 cm and 4 cm from the lesion. Two non-lesional sites at a 2 cm distance from the same lesion were collected to determine biological variability. Filaggrin degradation products (NMF) were determined by liquid chromatography and thirteen cytokines (IL-4, IL-13, IL-18, IL-31, IL- 33, CCL17, CCL22, CCL27, CXCL8, IL-1α, IL-RA, IL- 18, IL-22) by multiplex immunoassay. Results: Biomarker levels showed gradual changes from lesional to non-lesional skin sites at 2 cm and 4 cm ; magnitude and direction of change were biomarker-specific. Intra-subject variability ranged from 17.3% (NMF) to 85.1% (CXCL8). Biomarker levels from two stratum corneum depths were highly correlated ; several biomarkers showed significant depth dependence. Conclusion: Stratum corneum enables non-invasive collection of relevant immune and epidermal biomarkers, but biomarker-specific spatial and biological variability emphasizes the importance of standardized procedures for stratum corneum collection.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
IP-2018-01-5978 - Klinički biomarkeri atopijskog dermatitisa (ADBIOMARK) (Marinović, Branka, HRZZ - 2018-01) ( CroRIS)

Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi doi.org

Citiraj ovu publikaciju:

Jurakić Tončić, Ružica; Kežić, Sanja; Ljubojević Hadžavdić, Suzana; Marinović, Branka; Jakaša, Ivone
Stratum corneum biomarkers in atopic dermatitis: biological and spatial variability // The Open biomarkers journal, 10 (2020), 47-54 doi:10.2174/1875318302010010047 (međunarodna recenzija, članak, znanstveni)
Jurakić Tončić, R., Kežić, S., Ljubojević Hadžavdić, S., Marinović, B. & Jakaša, I. (2020) Stratum corneum biomarkers in atopic dermatitis: biological and spatial variability. The Open biomarkers journal, 10, 47-54 doi:10.2174/1875318302010010047.
@article{article, author = {Juraki\'{c} Ton\v{c}i\'{c}, Ru\v{z}ica and Ke\v{z}i\'{c}, Sanja and Ljubojevi\'{c} Had\v{z}avdi\'{c}, Suzana and Marinovi\'{c}, Branka and Jaka\v{s}a, Ivone}, year = {2020}, pages = {47-54}, DOI = {10.2174/1875318302010010047}, keywords = {atopic dermatitis, biomarkers, non-invasive, cytokines, filaggrin, stratum corneum}, journal = {The Open biomarkers journal}, doi = {10.2174/1875318302010010047}, volume = {10}, issn = {1875-3183}, title = {Stratum corneum biomarkers in atopic dermatitis: biological and spatial variability}, keyword = {atopic dermatitis, biomarkers, non-invasive, cytokines, filaggrin, stratum corneum} }
@article{article, author = {Juraki\'{c} Ton\v{c}i\'{c}, Ru\v{z}ica and Ke\v{z}i\'{c}, Sanja and Ljubojevi\'{c} Had\v{z}avdi\'{c}, Suzana and Marinovi\'{c}, Branka and Jaka\v{s}a, Ivone}, year = {2020}, pages = {47-54}, DOI = {10.2174/1875318302010010047}, keywords = {atopic dermatitis, biomarkers, non-invasive, cytokines, filaggrin, stratum corneum}, journal = {The Open biomarkers journal}, doi = {10.2174/1875318302010010047}, volume = {10}, issn = {1875-3183}, title = {Stratum corneum biomarkers in atopic dermatitis: biological and spatial variability}, keyword = {atopic dermatitis, biomarkers, non-invasive, cytokines, filaggrin, stratum corneum} }

Časopis indeksira:


  • Scopus


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