Pregled bibliografske jedinice broj: 1076360
Influence of saliva on the results of global laboratory coagulation tests
Influence of saliva on the results of global laboratory coagulation tests // Australian dental journal, 65 (2020), 3; 205-209 doi:10.1111/adj.12753 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1076360 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Influence of saliva on the results of global
laboratory coagulation tests
Autori
Špiljak, Bruno ; Šimunović, Luka ; Lapić, Ivana ; Rogić, Dunja ; Špalj, Stjepan ; Vuletić, Lea
Izvornik
Australian dental journal (0045-0421) 65
(2020), 3;
205-209
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
activated partial thromboplastin time ; blood coagulation ; prothrombin time ; unstimulated saliva
Sažetak
Background: Oral wounds inevitably come into contact with saliva which can affect the time needed for bleeding to stop. The influence of saliva can be non-specific, related to dilution of blood, and/or mediated by salivary factors that affect haemostasis directly. The aim of this study was to assess if mixing blood with an individual’s saliva would affect the rate of its coagulation measured by global coagulation tests, prothrombin time (PT) and activated partial thromboplastin time (APTT). Methods: The study included 30 healthy non- smoking volunteers. Paired blood and unstimulated saliva samples were obtained from each participant and PT and APTT were determined in blood, blood + saliva and blood + water mixtures. Coagulation tests were performed using the mechanical clot detection method. Results: PT was significantly longer in both blood + saliva and blood + water mixtures compared to blood alone. APTT was significantly longer only in blood + water mixture compared to blood. Conclusions: Similarly prolonged PT in both mixtures suggests that both saliva and water prolong coagulation evenly due to their non- specific effect of blood dilution. The finding that APTT was significantly prolonged only when blood was mixed with water could indicate presence of tissue factor in saliva, however, in a concentration too low to influence the results of PT.
Izvorni jezik
Engleski
Znanstvena područja
Dentalna medicina
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Rijeka,
Stomatološki fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
Luka Šimunović
(autor)
Bruno Špiljak
(autor)
Dunja Rogić
(autor)
Lea Vuletić
(autor)
Ivana Lapić
(autor)
Stjepan Špalj
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE