Naslov
The association of HLA system polymorphisms with the development of clinically significant red blood cell antibodies

Autori
Raos, Mirela, Zunec, Renata ; Gojceta, Koraljka ; Golubic Cepulic, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Vox Sanguinis / - , 2013, 236-236

Skup
23rd Regional Congress of the ISBT

Mjesto i datum
Amsterdam, Nizozemska, 02.06.2013. - 05.06.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HLA system polymorphisms ; clinically significant ; alloantibodies

Sažetak
HLA class II molecules form a peptide binding site. For polymorphism of the HLA system b1 domain of DRB1, DQB1 and DPB1 molecules are responsible. The diversity Alloimmunization is a known risk of transfusion therapy caused by the exposure to foreign red blood cell antigens. Because there are hundreds of polymorphic epitopes of blood groups each transfusion of red blood cell units is inevitably mismatched. However, alloimmunization is not observed in all transfused patients. Genetic factors that may influence the risk of alloimmunization are not sufficiently explored. HLA molecules, T helper cells, B cells, and cytokines may contribute to the recognition and presentation of foreign antigens and to the potency of immune responses that result in the production of antibodies. a1 and b1 domains of amino acids that form the peptide binding site is responsible for the specificity of binding peptides. Because the diversity of antigen-binding sites of HLA molecules is conditioned by the HLA alleles, the ability to bind peptides is under genetic

Izvorni jezik
Engleski

POVEZANOST RADA