Naslov
Severe immune hemolytic anemia associated with warm-reacting IgM autoantibodies: a diagnostic (and therapeutic) challenge

Autori
Raos, Mirela ; Lukic, Marija ; Burnac, Iva Lucija ; Plenkovic, Fini ; Aurer, Igor ; Golubic Cepulic, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Vox Sanguinis / - , 2016, 222-222

Skup
34th International Congress of the ISBT

Mjesto i datum
Dubai, Ujedinjeni Arapski Emirati, 03.09.2016. - 08.09.2016

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Immune hemolytic anemia, warm-reacting IgM autoantibodies

Sažetak
Autoimmune hemolytic anemia (AIHA) can present with severe intraand extravascular hemolysis. In warm AIHA (WAIHA), characterised by IgG autoantibodies, hemolysis is tipically extravascular ; however, complement-mediated intravascular hemolysis can be seen in “mixed” type AIHA, characterised by both IgG warm autoantibodies and IgM cold autoantibodies reactive up to 30 to 37°C, and in rare WAIHA caused by IgM warm autoantibodies. Diagnostic of IgM WAIHA is very difficult. It can be confused with cold agglutinin syndrome, caused by IgM cold autoantibodies reactive up to 30°C or with “mixed” type AIHA. Although death from WAIHA is considered rare (4–11%), it is particularly high (22%) in IgM WAIHA.

Izvorni jezik
Engleski

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