Naslov
The role of innate immunity in the pathogenesis of breast cancer

Autori
Grebić, Damir ; Gulić, Tamara ; Starčević, Alma ; Alvirović, Manuela ; Blagojević Zagorac, Gordana ; Valković Zujić, Petra ; Veljković Vujaklija, Danijela.

Izvornik
Breast care (1661-3791) 18 (2020); 1-10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
breast cancer ; immunotherapy ; NK cells ; tumour associate macrophages ; tumour microenvironment.

Sažetak
Background: Breast carcinoma is the most common malignant disease in the female population and one of the leading causes of death among women worldwide. One crucial hallmark of cancer is chronic inflammation where the immunosuppressive environment is dominant. The immunosuppressive environment is largely achieved by the interaction of tumour cells and infiltrating leukocytes. Summary: Usually, human macrophages and natural killer cells are involved in antitumor immunity. The therapeutic potential of this population against cancers has stimulated their study and led to the discovery of several different tumour associate macrophages and natural killer cell subsets, each of which is endowed with different immunoregulatory functions. Both heterogeneity and plasticity of the tumour associate macrophages and natural killer cell compartment, which are both tightly linked to the tumor microenvironment of different breast cancer type. Key Messages: The identification of specific tumour associate macrophages and natural killer cell subsets endowed with particular functional capabilities might help monitor tumor mediated responses in breast cancer patients. Currently, one of the most used strategies for breast cancer of newly diagnosed patients is neoadjuvant chemotherapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA