Naslov
Tardivna diskinezija u starijoj životnoj dobi
(Tardive dyskinesia in the elderly)

Autori
Križaj Grden, Aida ; Mimica, Ninoslav

Izvornik
Pharmaca : hrvatski časopis za farmakoterapiju (0031-6857) Suppl. 2 (2019); 172-176

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, stručni

Ključne riječi
antipsihotici ; faktori rizika ; starija dob ; tardivna diskinezija ; VMAT2
(antipsychotics ; risk factors ; tardive dyskinesia ; old age ; VMAT2)

Sažetak
Tardive dyskinesia (TD) is a neurologicat movement disorder that presents most often with involuntary, stereotypical oro-bbuco-lingual movement and occurs with chronic use of (conventional) neuroleptics.The pathophysiology is unclear, it is believed to occur due to chronic blockage of dopamine receptors. The prevalence is 20%, in the elderly up to 30%. The main risk factors are old age, long duration of illness and the cumulative dose of medication. VMAT2 inhibitors (valbenazine, deutetrabenazine) are the treatment of choice for TD, they are not yet approved in Croatia. Positive results are seen after switching to clozapine. Amantadine, levetiracetam, vitamin B6, clonazepam and Ginkgo biloba also show positive results. The use of botulinum toxin is being researched, and for extreme cases deep brain stimulation. A case report of a female patient age 65 who was treated for symptoms related to psycho-organic syndrome, was hospitalized after several months treatment with sulpiride, followed by short term treatment with hatoperidol and que1apine develops TD is presented. After switching to clozapine symptoms withdraw completely within two months.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Abstract in English.

POVEZANOST RADA