Naslov
Ferroptosis: regulated cell death
(Feroptoza: regulirana stanična smrt)

Autori
Čepelak, Ivana ; Dodig, Slavica ; Čepelak Dodig, Daniela

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 71 (2020), 2; 99-109

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
glutation peroksidaza 4 ; lipidna peroksidacija ; reaktivne kisikove vrste ; sustav Xc- ; željezo
(glutathione peroxidase 4 ; lipid peroxidation ; reactive oxygen species ; system Xc- ; iron)

Sažetak
Ferroptosis is a recently identified form of regulated cell death that differs from other known forms of cell death morphologically, biochemically, and genetically. The main properties of ferroptosis are free redox-active iron and consequent iron-dependent peroxidation of polyunsaturated fatty acids in cell membrane phospholipids, which results in the accumulation of lipid-based reactive oxygen species due to loss of glutathione peroxidase 4 activity. Ferroptosis has increasingly been associated with neurodegenerative diseases, carcinogenesis, stroke, intracerebral haemorrhage, traumatic brain injury, and ischemia-reperfusion injury. It has also shown a significant therapeutic potential in the treatment of cancer and other diseases. This review summarises current knowledge about and the mechanisms that regulate ferroptosis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA