Naslov
Sarcopenia among patients after allogeneic hematopoietic stem cell transplantation and the impact of chronic graft versus host disease

Autori
Ljubas Kelečić, Dina ; Lelas, Antonela ; Karas, Irena ; Desnica, Lana ; Vukić, Tamara ; Sabol, Ivan ; Vranešić Bender, Darija ; Serventi Seiwerth, Ranka ; Perić, Zinaida ; Duraković, Nadira ; Vitali Čepo, Dubravka ; Vrhovac, Radovan ; Nemet, Damir ; Pavletic, Steven ; Pulanić, Dražen ; Krznarić, Željko

Izvornik
Journal of cancer research and clinical oncology (0171-5216) 146 (2020); 2967-2978

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Sarcopenia ; Allo-HSCT ; cGVHD ; Malnutrition ; Hand-grip strength ; Vitamin D

Sažetak
Purpose This study investigated the frequency and characteristics of sarcopenia among patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with a specific focus on the chronic graft-versus-host disease (cGVHD) population and its association with malnutrition, vitamin D and clinical characteristics. Methods We assessed sarcopenia, vitamin D levels, and nutritional status in 73 patients who underwent allo-HSCT, of which 45 were diagnosed with cGVHD. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. Results Sarcopenia was diagnosed in 19.2% of patients after allo- HSCT with statistically no significant difference between cGVHD and non- cGVHD patients. The risk factor for sarcopenia was the male gender. Sarcopenia in allo-HSCT patients correlated strongly with malnutrition and with current corticosteroid treatment (p < 0.005). Among cGVHD patients sarcopenia additionally correlated strongly with the number of prior systemic immunosuppressive therapy lines (p < 0.005) and moderately with the intensity of immunosuppression, cGVHD severity global rating assessed by both the health care provider and the patient and joint and fascia cGVHD involvement (p < 0.05). Vitamin D deficiency was found in more than 54.8% of patients, but the correlation to sarcopenia was not found. Conclusion Sarcopenia was found to be common in long term survivors of allo-HSCT independently of the cGVHD diagnosis. Prospective longitudinal studies are needed for a better understanding of factors affecting the development of sarcopenia after allo-HSCT.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA