Pregled bibliografske jedinice broj: 1066891
Cigarette Smoking during Pregnancy: Effects on Antioxidant Enzymes, Metallothionein and Trace Elements in Mother-Newborn Pairs
Cigarette Smoking during Pregnancy: Effects on Antioxidant Enzymes, Metallothionein and Trace Elements in Mother-Newborn Pairs // Biomolecules, 10 (2020), 6; 892, 18 doi:10.3390/biom10060892 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1066891 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Cigarette Smoking during Pregnancy: Effects on
Antioxidant Enzymes, Metallothionein and Trace
Elements in Mother-Newborn Pairs
Autori
Pizent, Alica ; Lazarus, Maja ; Kovačić, Jelena ; Tariba Lovaković, Blanka ; Brčić Karačonji, Irena ; Živković Semren, Tanja ; Sekovanić, Ankica ; Orct, Tatjana ; Branović-Čakanić, Karmen ; Brajenović, Nataša ; Jurič, Andreja ; Miškulin, Iva ; Škrgatić, Lana ; Stasenko, Sandra ; Mioč, Tatjana ; Jurasović, Jasna ; Piasek, Martina
Izvornik
Biomolecules (2218-273X) 10
(2020), 6;
892, 18
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
toxic metals ; essential elements ; SOD ; GPx ; metallothionein ; sparse discriminant analysis ; developmental exposure ; maternal smoking
Sažetak
The effect of maternal smoking as a source of exposure to toxic metals Cd and Pb on superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity, metallothionein (MT), Cd, Pb, Cu, Fe, Mn, Se and Zn concentrations were assessed in maternal and umbilical cord blood and placenta in 74 healthy mother-newborn pairs after term delivery. Sparse discriminant analysis (SDA) was used to identify elements with the strongest impact on the SOD, GPx and MT in the measured compartments, which was then quantified by multiple regression analysis. SOD activity was lower in maternal and cord plasma, and higher in the placenta of smokers compared to non- smokers, whereas GPx activity and MT concentration did not differ between the groups. Although active smoking during pregnancy contributed to higher maternal Cd and Pb concentrations, its contribution to the variability of SOD, GPx or MT after control for other elements identified by SDA was not significant. However, an impaired balance in the antioxidant defence observed in the conditions of relatively low-to-moderate exposure levels to Cd and Pb could contribute to an increased susceptibility of offspring to oxidative stress and risk of disease development later in life. Further study on a larger number of subjects will help to better understand complex interactions between exposure to toxic elements and oxidative stress related to maternal cigarette smoking.
Izvorni jezik
Engleski
Znanstvena područja
Javno zdravstvo i zdravstvena zaštita
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-1998 - Procjena svakodnevne izloženosti metalima i osobne osjetljivosti majke kao čimbenika razvojnoga podrijetla zdravlja i bolesti (METALORIGINS) (Piasek, Martina; Jurasović, Jasna, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinička bolnica "Merkur",
Hrvatski veterinarski institut, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
Tanja Živković Semren
(autor)
Sandra Stasenko
(autor)
Ankica Sekovanić
(autor)
Lana Škrgatić
(autor)
Karmen Branović-Čakanić
(autor)
Nataša Brajenović
(autor)
Andreja Jurič
(autor)
Maja Lazarus
(autor)
Tatjana Orct
(autor)
Iva Miškulin
(autor)
Martina Piasek
(autor)
Jasna Jurasović
(autor)
Blanka Tariba
(autor)
Alica Pizent
(autor)
Jelena Kovačić
(autor)
Irena Brčić Karačonji
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Emerging Sources Citation Index (ESCI)
- Scopus
- MEDLINE